Grimm H
Institut für Medizinische Mikrobiologie und Klinische Chemie, Weingarten.
Arzneimittelforschung. 1987 Oct;37(10):1116-9.
Comparative in vitro Studies of the beta-Lactamase Inhibitory Effects of Clavulanic Acid and Sulbactam on Ampicillin-resistant Enterobacteria. Clavulanic acid and sulbactam alone are infective against Pseudomonas and enterococci. Staphylococci and enterobacteriaceae are inhibited by high concentrations not attainable under clinical conditions. Strains of Acinetobacter, especially A. lwoffii are susceptible to clavulanic acid and highly susceptible to sulbactam. The sulbactam-ampicillin combination is superior to clavulanic acid-ampicillin against C. freundii, Enterobacter spp. and M. morganii. The latter combination is superior against Klebsiella spp. and E. coli. Antagonistic effects are more frequent with the clavulanic acid combination (Enterobacter spp. and C. freundii) but are rarely observed with the sulbactam combination (Providencia spp. and P. rettgeri).
克拉维酸和舒巴坦对耐氨苄西林肠杆菌的β-内酰胺酶抑制作用的体外比较研究。单独的克拉维酸和舒巴坦对铜绿假单胞菌和肠球菌无感染活性。葡萄球菌和肠杆菌科细菌在临床条件下无法达到的高浓度时受到抑制。不动杆菌属菌株，尤其是鲁氏不动杆菌对克拉维酸敏感，对舒巴坦高度敏感。舒巴坦-氨苄西林组合在抗弗氏柠檬酸杆菌、肠杆菌属和摩根氏摩根菌方面优于克拉维酸-氨苄西林组合。后一种组合在抗克雷伯菌属和大肠杆菌方面更具优势。克拉维酸组合（肠杆菌属和弗氏柠檬酸杆菌）的拮抗作用更常见，但舒巴坦组合（普罗威登斯菌属和雷氏普罗威登斯菌）很少观察到拮抗作用。
