Department of Pathology, Bhagwan Mahaveer Cancer Hospital and Research Centre, Jaipur, Rajasthan, India.
Department of Pathology-Haematopathology, Bhagwan Mahaveer Cancer Hospital and Research Centre, Jaipur, Rajasthan, India.
Indian J Cancer. 2022 Jan-Mar;59(1):110-114. doi: 10.4103/ijc.IJC_741_20.
Non-immunoglobulin intracytoplasmic inclusions in plasma cells of multiple myeloma are very rare presentation. These are morphologically similar to Auer rods but chemically different from them. We studied two cases of multiple myeloma in a 60-year-old woman and 45-year-old man. In both cases, plasma cells of bone marrow aspirate revealed multiple Auer rod-like inclusions (ARLI). Sudan black B (SBB) and myeloperoxidase (MPO) cytochemistry were negative. Serum protein electrophoresis in both of them showed M spike, one with raised IgA-kappa levels, while the other with raised IgG-kappa levels. Very few case reports have been published in the literature and its prognostic implications are still unknown. Due to its rarity, it is important to distinguish such cases from acute myeloid leukemia and its exact incidence with its therapeutic and prognostic implications.
多发性骨髓瘤浆细胞中非免疫球蛋白细胞内包涵物是非常罕见的表现。这些包涵物在形态上与 Auer 小体相似，但在化学性质上与 Auer 小体不同。我们研究了两名患者，一名 60 岁女性和一名 45 岁男性，骨髓抽吸物中的浆细胞均显示出多个 Auer 棒状包涵物（ARLI）。苏丹黑 B（SBB）和髓过氧化物酶（MPO）细胞化学均为阴性。他们的血清蛋白电泳均显示 M 峰，其中一个伴有升高的 IgA-κ 水平，另一个伴有升高的 IgG-κ 水平。文献中仅发表了少数几例病例报告，其预后意义尚不清楚。由于其罕见性，重要的是要将此类病例与急性髓系白血病及其确切发病率及其治疗和预后意义区分开来。
