Anand Akshay, Ghani Abdul, Sharma Kanupriya, Kaur Gurkeerat, Khosla Radhika, Devi Chandra, Podder Vivek, Sivapuram Madhava S, Maity Kalyan, Kaur Harmandeep
Department of Neurology, Neuroscience Research Lab, Postgraduate Institute of Medical Education and Research, Panjab University, Chandigarh, India.
CCRYN Center for Mind Body Interventions through Yoga PGIMER, Chandigarh, India.
Int J Yoga. 2021 Sep-Dec;14(3):175-187. doi: 10.4103/ijoy.ijoy_60_21. Epub 2021 Nov 22.
Conflicts and humanitarian crises lead to serious mental health disorders, including depression, anxiety, stress, and cognitive decline. Exposure to these circumstances in early life can lead to the development of disorders such as mild cognitive impairment, dementia, and Alzheimer's disease (AD), for which no treatments are available. In this review, various research papers have been compiled to develop an understanding about mental health of population affected due to wars and conflicts and how stress and depression can accelerate the development of dementia and AD. Due to failure of drugs in the treatment of dementia and AD, yoga and mindfulness-based approach has been proposed for future investigations. Although studies have shown that yoga and mindfulness can be helpful in the management of stress, anxiety, depression, and posttraumatic stress disorder in the war-afflicted areas, limited mechanistic studies in yoga and mindfulness remain the chief cause precluding its clinical application in such warzones. The molecular studies in the field of yoga can be undertaken by targeting these warzones. This review provides a scientific evaluation of mind-body techniques as a justification for mental health rehabilitation in the war-afflicted zones in face of failed clinical trials for various drugs. This may help reduce the risk of developing dementia and AD in this susceptible population.
冲突和人道主义危机导致严重的心理健康障碍,包括抑郁症、焦虑症、压力和认知能力下降。早年暴露于这些环境会导致诸如轻度认知障碍、痴呆症和阿尔茨海默病(AD)等疾病的发生,而目前尚无针对这些疾病的治疗方法。在本综述中,收集了各种研究论文,以了解受战争和冲突影响人群的心理健康状况,以及压力和抑郁如何加速痴呆症和AD的发展。由于药物治疗痴呆症和AD失败,已提议未来对基于瑜伽和正念的方法进行研究。尽管研究表明瑜伽和正念有助于管理战乱地区的压力、焦虑、抑郁和创伤后应激障碍,但瑜伽和正念方面有限的机制研究仍然是阻碍其在这些战区临床应用的主要原因。瑜伽领域的分子研究可以针对这些战区进行。面对各种药物临床试验失败的情况,本综述对身心技术进行了科学评估,为战乱地区的心理健康康复提供了依据。这可能有助于降低这一易感人群患痴呆症和AD的风险。