Kumar Ram Elumalai, Gupta Nitin, Ranjan Rajeev, Verma Ritu, Belho Ethel Shangne, Sen Ishita Barat
Department of Nuclear Medicine and PET/CT, Mahajan Imaging Centre, Sir Ganga Ram Hospital, New Delhi, India.
Department of Neurology, Sir Ganga Ram Hospital, New Delhi, India.
World J Nucl Med. 2021 Nov 1;20(4):401-404. doi: 10.4103/wjnm.wjnm_135_20. eCollection 2021 Oct-Dec.
F-2-fluoro-2-deoxy-D-glucose ([F]-FDG) positron emission tomography (PET) CT has proven useful in the evaluation of high-grade glioma and is also useful as a predictor of the degree of malignancy in newly diagnosed brain tumors. It is commonly accepted that high-grade gliomas are characterized by increased FDG uptake, whereas the low-grade glioma demonstrates reduced or absent FDG uptake. [F]-FDOPA is an amino acid PET tracer which is a marker of the proliferative activity of brain tumors and demonstrates positive uptake in all grades of brain tumors; however, the degree of tracer uptake is significantly higher in high-grade tumors as compared to low-grade tumors. Here, we discuss a case where both FDG and DOPA PET/CT scans raised suspicion of low-grade glioma; however, the final histopathology report confirmed WHO grade IV Glioblastoma.
F-2-氟-2-脱氧-D-葡萄糖（[F]-FDG）正电子发射断层扫描（PET）CT已被证明在高级别胶质瘤的评估中有用，并且也可作为新诊断脑肿瘤恶性程度的预测指标。人们普遍认为，高级别胶质瘤的特征是FDG摄取增加，而低级别胶质瘤表现为FDG摄取减少或无摄取。[F]-FDOPA是一种氨基酸PET示踪剂，它是脑肿瘤增殖活性的标志物，在所有级别的脑肿瘤中均表现为阳性摄取；然而，与低级别肿瘤相比，高级别肿瘤中示踪剂的摄取程度明显更高。在此，我们讨论一例FDG和多巴PET/CT扫描均怀疑为低级别胶质瘤的病例；然而，最终的组织病理学报告证实为世界卫生组织IV级胶质母细胞瘤。
