新型可吸收性胰腺夹在猪的胰体尾切除术的疗效。
Efficacy of a newly developed bioabsorbable pancreatic clip for distal pancreatectomy in swine.
机构信息
Department of Gastroenterological Surgery, Graduate School of Life Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto, 860-8556, Japan.
Department of Chemical Engineering, Faculty of Engineering, Graduate School, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka, 819-0395, Japan.
出版信息
Surg Today. 2022 Jul;52(7):1109-1114. doi: 10.1007/s00595-021-02435-x. Epub 2022 Jan 12.
PURPOSE
At present, ≥ 20% of patients experience clinically relevant postoperative pancreatic fistula (POPF) after distal pancreatectomy (DP).
METHODS
We developed a new bioabsorbable pancreatic clip (BioPaC) made of polycaprolactone that does not crush the pancreatic parenchyma during occlusion of the pancreatic stump. We confirmed the efficacy of this BioPac in a porcine DP model and compared it to a linear stapling device (Reinforce®).
RESULTS
Pigs were killed at 1 month after DP. In the BioPaC group, all swine (n = 3) survived well without POPF. In the Reinforce® group (n = 2), one pig died early at postoperative day 7 with Grade C POPF (amylase 43 700 U/l), and the other survived until 1 month at scarification with biochemical leakage of POPF (amylase 3 725 U/l). Pathologically, the main pancreatic duct and pancreatic parenchyma were well closed by BioPaC.
CONCLUSION
The newly developed BioPaC is effective in a porcine DP model.
目的
目前，在远端胰腺切除术（DP）后，有≥20%的患者出现临床上相关的术后胰瘘（POPF）。
方法
我们开发了一种由聚己内酯制成的新型可吸收性胰腺夹（BioPaC），在夹闭胰腺残端时不会压碎胰腺实质。我们在猪 DP 模型中证实了这种 BioPac 的有效性，并将其与线性吻合器（Reinforce®）进行了比较。
结果
DP 后 1 个月处死猪。在 BioPaC 组中，所有猪（n=3）均无 POPF，且存活良好。在 Reinforce®组（n=2）中，一只猪在术后第 7 天因 C 级 POPF（淀粉酶 43700 U/L）而早期死亡，另一只猪在 1 个月时因生化漏 POPF（淀粉酶 3725 U/L）而存活。病理上，BioPaC 可很好地封闭主胰管和胰腺实质。
结论
新开发的 BioPaC 在猪 DP 模型中有效。
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