长期乙醇暴露会增强促肾上腺皮质激素释放因子（CRF）对大鼠的运动激活作用。
Chronic ethanol exposure potentiates the locomotor-activating effects of corticotropin-releasing factor (CRF) in rats.
作者信息
Ehlers C L, Chaplin R I
机构信息
Alcohol Research Center, Research Institute of the Scripps Clinic, La Jolla, CA 92037.
出版信息
Regul Pept. 1987 Dec;19(5-6):345-53. doi: 10.1016/0167-0115(87)90176-5.
The effects of chronic exposure (21 days) to ethanol vapors on locomotor response to intracerebroventricular (i.c.v.) administration of corticotropin releasing factor (CRF) was investigated in male Wistar rats. Responses to CRF were tested during chronic exposure, 1 1/2 hours following removal of ethanol vapors, and two weeks after withdrawal of ethanol. A greater sensitivity to the locomotor-activating effects of CRF was found in ethanol-treated rats as compared to their controls during ethanol exposure (P less than 0.001) and 90 min following removal of ethanol vapors (P less than 0.001) but not two weeks following withdrawal. These results support clinical findings of a reversible activation in the hypothalamic-pituitary-adrenal (HPA) axis in alcoholism. In addition, it appears that chronic exposure to ethanol can also modify central neuronal systems specifically responsive to the locomotor activating effects of CRF.
在雄性Wistar大鼠中，研究了长期暴露（21天）于乙醇蒸汽对脑室内注射促肾上腺皮质激素释放因子（CRF）后运动反应的影响。在长期暴露期间、去除乙醇蒸汽1.5小时后以及停止乙醇暴露两周后，测试对CRF的反应。与对照组相比，在乙醇暴露期间（P<0.001）和去除乙醇蒸汽90分钟后（P<0.001），乙醇处理的大鼠对CRF的运动激活作用表现出更高的敏感性，但在停止暴露两周后则没有。这些结果支持了酒精中毒时下丘脑-垂体-肾上腺（HPA）轴可逆激活的临床发现。此外，长期暴露于乙醇似乎还可以改变对CRF的运动激活作用有特异性反应的中枢神经系统。
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