The Scripps Research Institute, Molecular and Integrative Neurosciences Department, La Jolla, CA 92037, USA.
Behav Brain Res. 2010 Jul 11;210(2):164-70. doi: 10.1016/j.bbr.2010.02.021. Epub 2010 Feb 16.
Electrophysiological studies have shown that adolescent ethanol (EtOH) exposure can produce long-term changes in hippocampal EEG and ERP activity. Recently, evidence has emerged suggesting that event-related oscillations (EROs) may be good indices of alcoholism risk in humans, however, have not been evaluated for their ability to index the effects of EtOH exposure. The objective of the present study was to characterize EROs generated in hippocampus in adult rats exposed to EtOH during adolescence. Adolescent male Sprague-Dawley rats were exposed to EtOH vapor for 12h/d for 10 days. A time-frequency representation method was used to determine delta, theta, alpha and beta ERO energy and the degree of phase variation in the hippocampus of adult rats exposed to EtOH and age-matched controls. The present results suggest that the decrease in P3 amplitudes, previously observed in adult rats exposed to EtOH during adolescence, is associated with increases in evoked theta ERO energy. These studies suggest that EROs are suitable for characterizing the long-term effects of adolescent EtOH exposure. Further studies are needed to determine the relationship between the mechanisms that regulate these neurophysiological endophenotypes and the consequences of adolescent EtOH exposure.
电生理研究表明，青少年接触乙醇（EtOH）会导致海马脑电图和事件相关电位（ERP）活动产生长期变化。最近有证据表明，事件相关振荡（EROs）可能是评估人类酒精中毒风险的良好指标，但尚未评估其评估 EtOH 暴露影响的能力。本研究的目的是描述在青春期接触 EtOH 的成年大鼠海马中产生的 ERO。青春期雄性 Sprague-Dawley 大鼠每天暴露于 EtOH 蒸气中 12 小时，共 10 天。使用时频表示法确定在青春期接触 EtOH 和年龄匹配的对照组的成年大鼠海马中 δ、θ、α 和 β ERO 能量和相位变化程度。目前的结果表明，先前在青春期接触 EtOH 的成年大鼠中观察到的 P3 振幅降低与诱发的θ ERO 能量增加有关。这些研究表明，EROs 适合描述青少年 EtOH 暴露的长期影响。需要进一步研究来确定调节这些神经生理表型的机制与青少年 EtOH 暴露的后果之间的关系。
