College of Chemistry, Green Catalysis Center, Zhengzhou University, Zhengzhou 450052, People's Republic of China.
TetranovBiopharm, LLC., Zhengzhou, 450052, People's Republic of China.
Org Biomol Chem. 2022 Feb 2;20(5):989-994. doi: 10.1039/d1ob02318g.
An efficient copper-catalyzed cascade difunctionalization of -allyl anilines toward the synthesis of silylated indolines using commercially available silanes has been reported. This strategy provides a new avenue for the synthesis of a diverse array of indolines in reasonable yields. Preliminary mechanistic investigations indicate that the reaction probably proceeds a radical pathway with unactivated alkenes as radical acceptors and simple silanes as radical precursors. This protocol is distinguished by its atom economy, broad substrate scope and readily available starting materials.
本文报道了一种高效的铜催化 - 烯丙基苯胺的级联双官能化反应，通过使用商业可得的硅烷，合成了硅基取代的吲哚啉。该策略为合理产率下合成各种吲哚啉提供了一条新途径。初步的机理研究表明，该反应可能通过自由基途径进行，其中未活化的烯烃作为自由基受体，简单的硅烷作为自由基前体。该反应具有原子经济性、广泛的底物范围和易得的起始原料等优点。
