Nanjing Gulou Yi Yuan: Nanjing University Medical School Affiliated Nanjing Drum Tower Hospital, Intensive care unit Affiliated - Nanjing, China.
The First Affiliated Hospital of Nanjing Medical University, Department of Laboratory Medicine - Jiangsu, China.
Rev Assoc Med Bras (1992). 2021 Oct;67(10):1443-1447. doi: 10.1590/1806-9282.20210649.
Mean platelet volume is a simple biomarker for inflammatory disease. The purpose of this study is to evaluate the role of mean platelet volume in distinguishing adult-onset Still's disease from sepsis.
We retrospectively selected 68 patients with adult-onset Still's disease and 55 patients with sepsis between January 2015 and December 2019. Related laboratory data were collected and analyzed.
There were no significant differences in white blood cell counts, neutrophils, lymphocytes, and C-reactive protein between adult-onset Still's disease group and sepsis group. However, patients in adult-onset Still's disease group showed higher ferritin and platelets and lower mean platelet volume and platelet distribution width than those in sepsis group (p<0.01 for both). Receiver operating characteristic curve analysis was performed to distinguish adult-onset Still's disease and sepsis. The area under the curve of mean platelet volume was 0.761 (95%CI 0.673-0.849), with a sensitivity of 79.1%, a specificity of 63.3%, and a cutoff value of 10.9 fL. In contrast, the area under the curve of combined ferritin and mean platelet volume was 0.90l (95%CI 0.837-0.965), with higher sensitivity (82.8%) and specificity (96.2%). Therefore, mean platelet volume could be used as a supplementary indicator to distinguish adult-onset Still's disease from sepsis.
We suggest that mean platelet volume could be used as a supplementary biomarker for differential diagnosis of adult-onset Still's disease and sepsis in addition to ferritin.
平均血小板体积是炎症性疾病的一个简单生物标志物。本研究旨在评估平均血小板体积在鉴别成人Still 病与脓毒症中的作用。
我们回顾性选择了 2015 年 1 月至 2019 年 12 月期间 68 例成人Still 病患者和 55 例脓毒症患者。收集并分析了相关实验室数据。
成人Still 病组和脓毒症组的白细胞计数、中性粒细胞、淋巴细胞和 C 反应蛋白无显著差异。然而，与脓毒症组相比，成人Still 病组的铁蛋白和血小板较高，平均血小板体积和血小板分布宽度较低（均 P<0.01）。为鉴别成人Still 病和脓毒症进行了受试者工作特征曲线分析。平均血小板体积曲线下面积为 0.761（95%CI 0.673-0.849），灵敏度为 79.1%，特异性为 63.3%，截断值为 10.9 fL。相比之下，铁蛋白和平均血小板体积联合曲线下面积为 0.901（95%CI 0.837-0.965），具有更高的灵敏度（82.8%）和特异性（96.2%）。因此，平均血小板体积可作为鉴别成人Still 病和脓毒症的补充指标。
我们建议，平均血小板体积除铁蛋白外，还可作为鉴别成人Still 病和脓毒症的辅助诊断标志物。
