Li Tianyu, Pan Shuojiong, Zhuang Hao, Gao Shiqian, Xu Huaping
Key Lab of Organic Optoelectronics & Molecular Engineering, Department of Chemistry, Tsinghua University, Beijing 100084, People's Republic of China.
ACS Appl Bio Mater. 2020 Feb 17;3(2):1283-1292. doi: 10.1021/acsabm.9b01172. Epub 2020 Jan 23.
Developing multifunctional carrier-free nanomedicine with high efficacy attracts tremendous attention in cancer treatment. Here, we develop selenium-containing carrier-free assemblies with aggregation-induced emission (AIE) property, which achieve the combination of cancer radiotherapy with chemotherapy. Under γ-radiation, diselenide bonds in the assemblies can be cleaved to form seleninic acid, which exhibits anticancer activity by upregulating the reactive oxygen species (ROS) levels in cancer cells. The incorporation of AIE groups further endows the selenium-containing assemblies with the ability of bioimaging. Their self-assembly behavior change under γ-radiation can be consequently observed in situ. The system combines cancer radiotherapy with chemotherapy, which exhibits improved anticancer activity.
开发具有高效性的多功能无载体纳米药物在癌症治疗中引起了极大关注。在此，我们开发了具有聚集诱导发光（AIE）特性的含硒无载体组装体，实现了癌症放疗与化疗的联合。在γ辐射下，组装体中的二硒键可被裂解形成亚硒酸，其通过上调癌细胞中的活性氧（ROS）水平发挥抗癌活性。AIE基团的引入进一步赋予含硒组装体生物成像能力。因此，可以原位观察到它们在γ辐射下的自组装行为变化。该系统将癌症放疗与化疗相结合，表现出增强的抗癌活性。
