Key Lab of Organic Optoelectronics & Molecular Engineering, Department of Chemistry, Tsinghua University, Beijing, 100084, P. R. China.
Tsinghua-Peking Joint Center for Life Sciences, Beijing, 100084, P. R. China.
Adv Mater. 2020 Mar;32(12):e1907568. doi: 10.1002/adma.201907568. Epub 2020 Feb 13.
Considering the limited clinical benefits of individual approaches against malignancy, natural killer (NK) cell-mediated immunotherapy is increasingly utilized in combination with radiotherapy and target therapeutics. However, the interplay of targeted agents, immunotherapy, and radiotherapy is complex. An improved understanding of the effect of chemotherapy or radiotherapy on specific molecular pathways in immune cells would help to optimize the synergistic antitumor efficiency. In this study, the selenium-containing nanoparticles (NPs) could deliver the chemotherapeutic drug doxorubicin (DOX) to tumor sites by systemic administration. Radiation stimuli facilitate DOX release and enhance chemotherapy efficiency. Moreover, radiation could oxidize diselenide-containing NPs to seleninic acid, which have both synergistic antitumor effect and immunomodulatory activity through enhancing NK cells function. These results indicate that the selenium-containing NPs would be a potential approach to achieve simultaneous treatments of immunotherapy, chemotherapy, and radiotherapy by a simple but effective method.
考虑到针对恶性肿瘤的单一方法的临床获益有限，自然杀伤 (NK) 细胞介导的免疫疗法越来越多地与放射治疗和靶向治疗联合使用。然而，靶向药物、免疫疗法和放射疗法的相互作用非常复杂。更好地了解化疗或放疗对免疫细胞中特定分子途径的影响，将有助于优化协同抗肿瘤效率。在这项研究中，含硒纳米颗粒 (NPs) 可以通过全身给药将化疗药物阿霉素 (DOX) 递送到肿瘤部位。辐射刺激促进 DOX 释放并提高化疗效率。此外，辐射可以将含二硒化物的 NPs 氧化为亚硒酸，通过增强 NK 细胞的功能，具有协同抗肿瘤作用和免疫调节活性。这些结果表明，通过简单而有效的方法，含硒 NPs 将成为同时进行免疫疗法、化疗和放疗的潜在方法。
