Chen Mengjun, Yin Keyang, Zhang Geping, Liu Huizhong, Ning Bo, Dai Youyong, Wang Xiaojing, Li Hongguang, Hao Jingcheng
Key Laboratory of Colloid and Interface Chemistry & Key Laboratory of Special Aggregated Materials, Shandong University, Ministry of Education, Jinan 250100, China.
School of Qilu Transportation, Shandong University, Jinan 250002, China.
ACS Appl Bio Mater. 2020 Jan 21;3(1):358-368. doi: 10.1021/acsabm.9b00857. Epub 2019 Dec 13.
Fullerene C (refers to C hereafter) has a unique three-dimensional architecture and intriguing physicochemical properties. It has great potential applications in materials chemistry and life science. However, a big obstacle for the widespread application of C lies in the limited strategies to make supramolecular structures with diverse morphologies and functions. Herein, we report a strategy to prepare C-based, magnetic microcapsules which can be used as external antioxidants to effectively attenuate oxidative stress. The microcapsules are composed of fullerenol, a highly water-soluble C multiadduct, and iron ions (Fe) released from a rusty nail. They can be easily obtained through coordination between the hydrophilic functional groups in fullerenol and Fe with polystyrene microspheres as templates. The fullerenol/Fe microcapsules have good colloidal stability both in water and serum. Their biocompatibility has been confirmed by in vitro tests on HEK293 and Hela cells. Electron spin resonance measurements indicate that the fullerenol/Fe microcapsules can effectively scavenge hydroxyl radicals (OH·) produced by HO, which greatly improves the living environment of the cells. The fullerenol/Fe microcapsules exhibit ferromagnetic properties and can respond to the external magnetic field, enabling magnetic manipulation, and/or separation in practical applications.
富勒烯C（以下简称C）具有独特的三维结构和引人关注的物理化学性质。它在材料化学和生命科学领域具有巨大的潜在应用价值。然而，C广泛应用的一个重大障碍在于制备具有多样形态和功能的超分子结构的策略有限。在此，我们报道了一种制备基于C的磁性微胶囊的策略，该微胶囊可用作外部抗氧化剂以有效减轻氧化应激。这些微胶囊由富勒醇（一种高度水溶性的C多加成物）和从生锈钉子中释放出的铁离子（Fe）组成。它们可以通过以聚苯乙烯微球为模板，利用富勒醇中的亲水性官能团与Fe之间的配位作用轻松获得。富勒醇/Fe微胶囊在水和血清中均具有良好的胶体稳定性。它们的生物相容性已通过对HEK293和Hela细胞的体外测试得到证实。电子自旋共振测量表明，富勒醇/Fe微胶囊可以有效清除由HO产生的羟基自由基（OH·），这极大地改善了细胞的生存环境。富勒醇/Fe微胶囊表现出铁磁性质，能够响应外部磁场，从而在实际应用中实现磁性操控和/或分离。
