Hong Jin-Hyeok, Totani Masayasu, Kawaguchi Daisuke, Masunaga Hiroyasu, Yamada Norifumi L, Matsuno Hisao, Tanaka Keiji
Department of Applied Chemistry, Kyushu University, Fukuoka 819-0395, Japan.
Centre for Polymer Interface and Molecular Adhesion Science, Kyushu University, Fukuoka 819-0395, Japan.
ACS Appl Bio Mater. 2020 Nov 16;3(11):7363-7368. doi: 10.1021/acsabm.0c01118. Epub 2020 Oct 28.
We designed an amphiphilic block copolymer, poly(methyl methacrylate)--poly[oligo(2-ethyl-2-oxazoline) methacrylate] (PMMA--P[O(Ox)MA]), suitable for bioinert coating. Angular-dependent X-ray photoelectron spectroscopy and neutron reflectivity measurements revealed that the outermost surface of a dried film of PMMA--P[O(Ox)MA] was covered with the PMMA block-rich layer. Once the film came into contact with water, the P[O(Ox)MA] bottlebrush block was segregated toward the water interface. This structural rearrangement in the outermost region of the film resulted in the formation of the swollen oligo(oxazoline) layer with excellent bioinertness in terms of the suppression of serum protein adsorption and NIH3T3 fibroblast adhesion.
我们设计了一种两亲性嵌段共聚物，聚（甲基丙烯酸甲酯）-聚[低聚（2-乙基-2-恶唑啉）甲基丙烯酸酯]（PMMA-P[O(Ox)MA]），适用于生物惰性涂层。角分辨X射线光电子能谱和中子反射率测量表明，PMMA-P[O(Ox)MA]干膜的最外表面覆盖着富含PMMA嵌段的层。一旦该膜与水接触，P[O(Ox)MA]刷状嵌段就会向水界面偏析。膜最外层区域的这种结构重排导致形成了具有优异生物惰性的肿胀低聚恶唑啉层，在抑制血清蛋白吸附和NIH3T3成纤维细胞黏附方面表现出色。
