Cheng Quan, Li Tuanwei, Tian Youliang, Dang Huiping, Qian Hongyun, Teng Changchang, Xie Kai, Yan Lifeng
CAS Key Laboratory of Soft Matter Chemistry, Hefei National Laboratory for Physical Sciences at the Microscale, and Department of Chemical Physics, University of Science and Technology of China, Hefei 230026, P. R.China.
ACS Appl Bio Mater. 2020 Dec 21;3(12):8953-8961. doi: 10.1021/acsabm.0c01218. Epub 2020 Nov 19.
NIR-II fluorescence imaging-guided photothermal therapy is a potential tumor therapeutic that has exhibited accurate diagnosis and noninvasive therapy of tumors. Here, we developed an organic macromolecular nanoparticle (PFD) by encapsulating a fluorophore with an amphiphilic polypeptide. The PFD nanoparticle presented a uniform size of 70 nm with a slightly negative charge and exhibited superior photothermal conversion efficiency (40.69%), thermal imaging ability, and considerable photothermal stability. The PFD nanoparticle could accumulate at the tumor site by an enhanced penetration and retention effect and exhibited satisfactory fluorescence imaging and prominent photothermal inhibition effect. In vivo experiments demonstrated that PFD nanoparticles exhibited a prominent photothermal inhibition effect against the tumor. Meanwhile, the therapeutic procedure was monitored by both NIR-II fluorescence and infrared thermal imaging, which demonstrated that the PFD nanoparticles have a potential application in imaging-guided photothermal therapy of tumors.
近红外二区荧光成像引导的光热疗法是一种具有潜力的肿瘤治疗方法，已展现出对肿瘤的准确诊断和非侵入性治疗能力。在此，我们通过用两亲性多肽包裹荧光团，制备了一种有机大分子纳米颗粒（PFD）。PFD纳米颗粒尺寸均匀，为70纳米，带轻微负电荷，具有优异的光热转换效率（40.69%）、热成像能力和相当的光热稳定性。PFD纳米颗粒可通过增强渗透滞留效应在肿瘤部位聚集，展现出令人满意的荧光成像和显著的光热抑制效果。体内实验表明，PFD纳米颗粒对肿瘤具有显著的光热抑制作用。同时，通过近红外二区荧光和红外热成像对治疗过程进行监测，结果表明PFD纳米颗粒在肿瘤成像引导光热治疗中具有潜在应用价值。
