Two-Dimensional Nanomaterials for Photoinduced Antibacterial Applications.

Nanomaterials used as novel antimicrobial agents are developed to combat wide-spectrum bacteria as well as alleviate the problem of bacterial resistance to traditional antibiotics. Two-dimensional (2D) nanomaterials are regarded as promising and widely applicable wide-spectrum antibacterial nanoagents due to their outstanding characteristics, including large surface area, stable structure, good biocompatibility, and cheap raw materials, especially excellent photocatalytic or photothermal properties. The advantages of less resistance, rapid sterilization, local action mode, and non-invasive make 2D nanomaterials with photoinduced property stand out in novel sterilization agents. Here, we systematically summarize various kinds of 2D nanomaterials that were used in photoinduced antibacterial field and introduce the synthesis methods and physicochemical properties related to antibacterial capability. Besides, the sterilization mechanisms of different 2D nanomaterials are also introduced in detail including a direct temperature generation, ROS production or ROS-independent oxidative stress, or various synergistic antibacterial modes. Lastly, we have also discussed the current problems of 2D nanomaterials as light-inducing antibacterial agents and their future application prospects in the fields of biomedicine, sewage treatment, food, and other application scenarios. We envision that this review will assist investigators with quick and in-depth understanding of the latest progress in 2D nanomaterials for photoinduced sterilization, inspiring the development of multiply strategies to design and synthesize novel 2D materials with strong bactericidal capability and high biological safety, and expand 2D materials with photoinduced sterilization to more application scenarios.