Carenini G, de Meglio P, Gentili P, Manzardo S
Maggioni Winthrop S.p.A., Laboratori Ricerche, Milano.
Farmaco Sci. 1987 Nov;42(11):861-71.
Some derivatives of trans-1-(4-phenylcyclohexyl)ethylamine (A) with a substituent at position 4 of the phenyl group were prepared and tested for antireserpine activity on the CNS. All compounds showed reduced activity compared with that of (A) except the amino derivative (II) which proved more active but at the same time showed increased toxicity and other adverse effects on the CNS.
制备了反式-1-(4-苯基环己基)乙胺(A)在苯基4位带有取代基的一些衍生物，并测试了它们对中枢神经系统的抗利血平活性。与(A)相比，所有化合物的活性均降低，除了氨基衍生物(II)，它被证明活性更高，但同时对中枢神经系统的毒性和其他不良反应也增加。
