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激活 Nrf2/HO-1 信号通路：中药治疗动脉粥样硬化保护血管内皮细胞免受氧化应激损伤的重要分子机制。

Activation of Nrf2/HO-1 signaling: An important molecular mechanism of herbal medicine in the treatment of atherosclerosis the protection of vascular endothelial cells from oxidative stress.

机构信息

School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611130, PR China.

出版信息

J Adv Res. 2021 Jul 6;34:43-63. doi: 10.1016/j.jare.2021.06.023. eCollection 2021 Dec.

DOI:10.1016/j.jare.2021.06.023
PMID:35024180
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8655139/
Abstract

INTRODUCTION: Recently, Nrf2/HO-1 has received extensive attention as the main regulatory pathway of intracellular defense against oxidative stress and is considered an ideal target for alleviating endothelial cell (EC) injury. OBJECTIVES: This paper aimed to summarized the natural monomers/extracts that potentially exert protective effects against oxidative stress in ECs. METHODS: A literature search was carried out regarding our topic with the keywords of "atherosclerosis" or "Nrf2/HO-1" or "vascular endothelial cells" or "oxidative stress" or "Herbal medicine" or "natural products" or "natural extracts" or "natural compounds" or "traditional Chinese medicines" based on classic books of herbal medicine and scientific databases including Pubmed, SciFinder, Scopus, the Web of Science, GoogleScholar, BaiduScholar, and others. Then, we analyzed the possible molecular mechanisms for different types of natural compounds in the treatment of atherosclerosis via the protection of vascular endothelial cells from oxidative stress. In addition, perspectives for possible future studies are discussed. RESULTS: These agents with protective effects against oxidative stress in ECs mainly include phenylpropanoids, flavonoids, terpenoids, and alkaloids. Most of these agents alleviate cell apoptosis in ECs due to oxidative stress, and the mechanisms are related to Nrf2/HO-1 signaling activation. However, despite continued progress in research on various aspects of natural agents exerting protective effects against EC injury by activating Nrf2/HO-1 signaling, the development of new drugs for the treatment of atherosclerosis (AS) and other CVDs based on these agents will require more detailed preclinical and clinical studies. CONCLUSION: Our present paper provides updated information of natural agents with protective activities on ECs against oxidative stress by activating Nrf2/HO-1. We hope this review will provide some directions for the further development of novel candidate drugs from natural agents for the treatment of AS and other CVDs.

摘要

简介：最近，Nrf2/HO-1 作为细胞内抗氧化应激的主要调节途径受到广泛关注，被认为是缓解内皮细胞 (EC) 损伤的理想靶点。

目的：本文旨在总结具有抗氧化应激保护作用的天然单体/提取物。

方法：根据经典草药书籍和包括 Pubmed、SciFinder、Scopus、Web of Science、Google Scholar、百度学术等在内的科学数据库中的关键词“动脉粥样硬化”或“Nrf2/HO-1”或“血管内皮细胞”或“氧化应激”或“草药”或“天然产物”或“天然提取物”或“天然化合物”或“中药”，对我们的主题进行文献检索。然后，我们分析了不同类型的天然化合物通过保护血管内皮细胞免受氧化应激治疗动脉粥样硬化的可能分子机制。此外，还讨论了未来研究的可能方向。

结果：这些具有抗氧化应激保护作用的药物主要包括苯丙素类、类黄酮类、萜类和生物碱类。这些药物中的大多数由于氧化应激而减轻 EC 中的细胞凋亡，其机制与 Nrf2/HO-1 信号通路的激活有关。然而，尽管在天然药物通过激活 Nrf2/HO-1 信号通路发挥对 EC 损伤的保护作用的各个方面的研究不断取得进展，但基于这些药物开发治疗动脉粥样硬化 (AS) 和其他 CVD 的新药仍需要更详细的临床前和临床研究。

结论：本文提供了通过激活 Nrf2/HO-1 具有抗氧化应激保护活性的天然药物在 EC 中的最新信息。我们希望这篇综述能为进一步开发新型候选药物提供一些方向，用于治疗 AS 和其他 CVD。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a34/8655139/b7204d6fc169/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a34/8655139/140247934b14/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a34/8655139/02abe8569f45/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a34/8655139/0b84c574851f/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a34/8655139/b7204d6fc169/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a34/8655139/140247934b14/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a34/8655139/02abe8569f45/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a34/8655139/0b84c574851f/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a34/8655139/b7204d6fc169/gr3.jpg

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