Welch T R, Berry A
Children's Hospital Research Foundation, Cincinnati, Ohio.
Dis Markers. 1987 Jun;5(2):81-7.
C3 genetic polymorphism was examined by immunofixation electrophoresis in 100 healthy controls and in patients with three diseases in which this complement protein appears to be involved pathogenically (IgA nephropathy 31; membranoproliferative glomerulonephritis 33; systemic lupus erythematosus 30). C3S (0.80) and C3F (0.20) frequencies in controls were similar to those published in the literature, as were the frequencies of the C3 phenotypes C3S (0.65), C3SF (0.29), and C3F (0.06). No patient group had frequencies which differed significantly from controls. Thus, the previously reported association between C3*F and IgA nephropathy was not confirmed, and no relationships between C3 polymorphism and systemic lupus erythematosus or membranoproliferative glomerulonephritis were recognized.
采用免疫固定电泳法检测了100名健康对照者以及三种疾病患者的C3基因多态性，这三种疾病中补体蛋白C3似乎在发病机制中发挥作用（IgA肾病31例；膜增生性肾小球肾炎33例；系统性红斑狼疮30例）。对照者中C3S（0.80）和C3F（0.20）的频率与文献报道的相似，C3表型C3S（0.65）、C3SF（0.29）和C3F（0.06）的频率也是如此。没有患者组的频率与对照者有显著差异。因此，先前报道的C3*F与IgA肾病之间的关联未得到证实，也未发现C3多态性与系统性红斑狼疮或膜增生性肾小球肾炎之间存在关联。
