巴西帕拉纳州人群中流行的基孔肯雅病毒的遗传特征。
Genetic characterization of Chikungunya virus circulating in individuals from Paraná, Brazil.
机构信息
Universidade Estadual de Maringá-UEM, Avenida Colombo, Maringá, Paraná, 5790, 87020-900, Brazil.
Faculdade de Medicina da Universidade de São Paulo - USP, São Paulo, Brazil.
出版信息
Braz J Microbiol. 2022 Jun;53(2):641-645. doi: 10.1007/s42770-022-00680-x. Epub 2022 Jan 14.
Phylogenetic analysis carried out in several Brazilian regions shows the circulation of the Asian and East-Central South African (ECSA) Chikungunya virus (CHIKV) genotypes in the country. Until now, there are no genetic studies about CHIKV strains circulating in the South region. In this study, we sequenced 5 new partial sequences of the CHIKV Envelope 1 gene from strains detected in Paraná state during the years 2016-2017. Maximum likelihood and neighbor-joining trees grouped all sequences in Brazilian branches within ECSA genotype and comparative analysis did not show E1-A226V mutation. However, we identified E1-K211T amino acid substitution in a sample demonstrating the dispersion of mutant strains in the country.
在巴西多个地区进行的系统发育分析显示，该国存在亚洲和中东南非（ECSA）基孔肯雅热病毒（CHIKV）基因型的循环。到目前为止，还没有关于在南部地区流行的 CHIKV 株的遗传研究。在这项研究中，我们对 2016 年至 2017 年在巴拉那州检测到的 CHIKV 毒株的 5 个新的包膜 1 基因部分序列进行了测序。最大似然和邻接法树将所有序列分组在 ECSA 基因型的巴西分支内，比较分析显示 E1-A226V 突变不存在。然而，我们在一个样本中发现了 E1-K211T 氨基酸取代，表明突变株在该国的传播。
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