在巴西东南部的一次疫情中检测到东/中/南非基因型基孔肯雅病毒。
Detection of East/Central/South African genotype Chikungunya virus during an outbreak in a southeastern state of Brazil.
机构信息
Fundação Oswaldo Cruz, Bio-Manguinhos,Rio de Janeiro, RJ,Brazil.
Fundação Oswaldo Cruz, Instituto Oswaldo Cruz,Rio de Janeiro, RJ,Brazil.
出版信息
Epidemiol Infect. 2018 Dec;146(16):2056-2058. doi: 10.1017/S0950268818002467. Epub 2018 Sep 5.
Abstract
Chikungunya virus (CHIKV) is an arbovirus transmitted by Aedes mosquitoes that was first identified in Brazil in 2014. It causes a febrile illness characterised by severe arthralgia and rash. Our group investigated a suspected CHIKV outbreak in Governador Valadares, state of Minas Gerais, Brazil and from 25 acute-phase patients, 10 had qRT-PCR positive sera samples and had E1 partial sequence amplified and Sanger sequenced. Samples were identified as East/Central/South African (ECSA) genotype by phylogenetic analysis and clustered with CHIKV sequences isolated in the neighbour state of Bahia. Our findings confirm previous predictions that ECSA genotype would spread through northeast and southeast of Brazil.
摘要
基孔肯雅热病毒（CHIKV）是一种由埃及伊蚊传播的虫媒病毒，于 2014 年在巴西首次被发现。它引起一种以严重关节炎和皮疹为特征的发热疾病。我们的小组调查了巴西米纳斯吉拉斯州州长瓦拉达里斯的一起疑似基孔肯雅热病毒暴发事件，从 25 例急性患者中，有 10 例 qRT-PCR 阳性血清样本，并扩增了 E1 部分序列并进行了 Sanger 测序。通过系统进化分析，这些样本被鉴定为东/中非/南非（ECSA）基因型，并与在相邻的巴伊亚州分离的基孔肯雅热病毒序列聚类。我们的研究结果证实了先前的预测，即 ECSA 基因型将在巴西东北部和东南部传播。
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