鉴定 RAGE 和 OSM 作为严重肺炎的新预后生物标志物。
Identification of RAGE and OSM as New Prognosis Biomarkers of Severe Pneumonia.
机构信息
Department of Respiratory and Critical Medicine, Nanjing First Hospital, Nanjing Medical University, Nanjing 210000, China.
出版信息
Can Respir J. 2022 Jan 7;2022:3854191. doi: 10.1155/2022/3854191. eCollection 2022.
OBJECTIVE
To investigate efficiency of RAGE and OSM as new prognosis biomarkers of severe pneumonia.
METHODS
Eligible patients were classified into hypoxemia and nonhypoxemia groups. Meanwhile, the same cohort was divided into survival and nonsurvival groups after a post-hospital stay of 30 days. We analyzed risk factors for the hypoxia and death among these patients.
RESULTS
Compared with nonsurvival group, significant increase was noticed in PH, lymphocyte, albumin and platelet level in survival group, while significant decline was noticed in neutrophils, RBC, hemoglobin, hematocrit, creatinine, total bilirubin, CRP, PCT, OSM, RAGE and neutrophils/lymphocyte level. Oxygenation index level was related to APACHE II, LIS, SOFA, NUTRIC score, WBC, neutrophils, lymphocyte, RAGE, and albumin level ( < 0.05). LIS, SOFA, NUTRIC score, lac, lymphocyte, platelet, BUN, total bilirubin, PCT, and OSM levels were associated with mortality rate ( < 0.05).
CONCLUSIONS
RAGE and OSM may serve as a new biomarker for poor prognosis in pneumonia patients.
目的
探讨 RAGE 和 OSM 作为严重肺炎新预后生物标志物的效率。
方法
将符合条件的患者分为低氧血症和非低氧血症组。同时，在住院 30 天后，将同一队列分为存活组和非存活组。我们分析了这些患者发生低氧血症和死亡的危险因素。
结果
与非存活组相比，存活组的 PH、淋巴细胞、白蛋白和血小板水平显著升高，而中性粒细胞、RBC、血红蛋白、血细胞比容、肌酐、总胆红素、CRP、PCT、OSM、RAGE 和中性粒细胞/淋巴细胞水平显著下降。氧合指数水平与 APACHE II、LIS、SOFA、NUTRIC 评分、白细胞、中性粒细胞、淋巴细胞、RAGE 和白蛋白水平相关（<0.05）。LIS、SOFA、NUTRIC 评分、乳酸、淋巴细胞、血小板、BUN、总胆红素、PCT 和 OSM 水平与死亡率相关（<0.05）。
结论
RAGE 和 OSM 可能成为肺炎患者预后不良的新生物标志物。
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