Wilson J D, George F W, Leshin M
Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas 75235.
Steroids. 1987 Jul-Sep;50(1-3):235-44. doi: 10.1016/0039-128x(83)90074-0.
Feminization of feathers in the Sebright cock is the result of increase in the activity of skin aromatase. This increased estrogen synthesis is the consequence of an autosomal dominant mutation that causes an increase in the specific androgen-binding cytochrome P450 oxidase involved in the reaction. Since this oxidase appears to be kinetically indistinguishable from the activity in control ovary we believe that the mutation causes an increased steady-state level of normal enzyme. The mechanism by which the mutation acts is unknown, but its presence implies that in normal birds an allele of the mutation limits the activity of the enzyme in all tissues other than ovary.
塞布赖特公鸡羽毛的雌性化是皮肤芳香化酶活性增加的结果。这种雌激素合成增加是常染色体显性突变的结果，该突变导致参与该反应的特定雄激素结合细胞色素P450氧化酶增加。由于这种氧化酶在动力学上似乎与对照卵巢中的活性没有区别，我们认为该突变导致正常酶的稳态水平增加。突变起作用的机制尚不清楚，但其存在意味着在正常鸟类中，该突变的一个等位基因限制了卵巢以外所有组织中该酶的活性。
