新型阳离子-CF BODIPY 基 AIE 荧光转子用于线粒体粘度成像。
Novel cationic -CF BODIPY-based AIE fluorescent rotors for imaging viscosity in mitochondria.
机构信息
School of Chemistry and Chemical Engineering, Guangzhou University, Guangzhou 510006, P. R. China.
School of Biology and Biological Engineering, South China University of Technology, Guangzhou 510006, P. R. China.
出版信息
Chem Commun (Camb). 2022 Feb 8;58(12):1930-1933. doi: 10.1039/d1cc06532g.
Two novel -CF BODIPY-based fluorescent rotors have been rationally prepared and found to sensitively respond to viscosity in living cells with a fluorescence "turn-on" effect, attributed to the special restricted rotation of -CF group in viscous environments. Interestingly, a monostyryl probe with one cationic group exhibits good mitochondrial localization and AIE property.
两种新型基于-CF BODIPY 的荧光转子已被合理制备，并发现它们在活细胞中对粘度具有灵敏的响应，表现出荧光“开启”效应，这归因于 -CF 基团在粘性环境中的特殊受限旋转。有趣的是，具有一个阳离子基团的单取代苯乙烯探针表现出良好的线粒体定位和聚集诱导发光（AIE）性质。
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