Katchen M, Duvoisin R C
UMDNJ-Robert Wood Johnson Medical School, Department of Neurology, New Brunswick 08903.
Mov Disord. 1986;1(2):151-7. doi: 10.1002/mds.870010210.
Three patients who presented initially with dystonia and subsequently developed typical idiopathic parkinsonism were evaluated. One patient presented with a writer's cramp, one with axial dystonia, and one with Meige syndrome. All three displayed amelioration of their dystonia with progression of their parkinsonism over a period of 2 to 15 years. Treatment with levodopa gave some relief of the parkinsonism symptoms in two patients but exacerbated or reactivated the dystonia. It is suggested that both the dystonia and the parkinsonism represent the changing clinical expression of the same disorder at different times in its evolution.
对3例最初表现为肌张力障碍并随后发展为典型特发性帕金森病的患者进行了评估。1例患者表现为书写痉挛，1例为轴性肌张力障碍，1例为Meige综合征。在2至15年的时间里，随着帕金森病的进展，这3例患者的肌张力障碍均有所改善。左旋多巴治疗使2例患者的帕金森病症状得到了一定缓解，但加重或再次激活了肌张力障碍。提示肌张力障碍和帕金森病均代表了同一疾病在其演变过程中不同时期不断变化的临床表型。
