由甘胆树脂-明胶复凝聚法制备微胶囊。I. 技术的发展

Preparation of microcapsules from complex coacervation of Gantrez-gelatin. I. Development of the technique.

作者信息

Mortada S A, Motawi A M, el Egaky A M, el-Khodery K A

机构信息

Department of Industrial Pharmacy, Faculty of Pharmacy, Alexandria University, Egypt.

出版信息

J Microencapsul. 1987 Jan-Mar;4(1):11-21. doi: 10.3109/02652048709031580.

DOI:10.3109/02652048709031580

PMID:3504493

Abstract

Trials to induce complex coacervation between two grades Gantrez-AN polymer (G-AN), and Type A gelatin were made. Physical parameters influencing the coacervation process were studied. Maximum coacervation was attained when the pH of the gelatin solution was at 6.8. Increasing the molecular weight of Gantrez decreased the ratio of combination of both polymers. The ratio for optimum coacervation was 1:4 for Gantrez-AN 119-gelatin system and 2:3 for Gantrez-AN 149-gelatin system with total colloid concentration of 2.5 g per cent w/v in both cases. High stirring speed gave almost spherical uniform coacervates. Recovery of the product as water-insoluble discrete units required the use of formaldehyde and isopropanol for coacervate denaturation and flocculation, respectively.

摘要

进行了诱导两种不同等级的甘特里兹 - AN聚合物（G - AN）与A型明胶之间形成复合凝聚的试验。研究了影响凝聚过程的物理参数。当明胶溶液的pH值为6.8时，达到最大凝聚。增加甘特里兹的分子量会降低两种聚合物的结合比例。对于甘特里兹 - AN 119 - 明胶体系，最佳凝聚比例为1:4；对于甘特里兹 - AN 149 - 明胶体系，最佳凝聚比例为2:3，两种情况下总胶体浓度均为2.5%（重量/体积）。高搅拌速度可得到几乎呈球形的均匀凝聚物。要将产物回收为水不溶性离散单元，分别需要使用甲醛使凝聚物变性和使用异丙醇使凝聚物絮凝。