Department of Science & Humanities, National Institute of Technology Nagaland, Chumukedima, Dimapur, 797103, Nagaland, India.
Department of Chemistry, Gauhati University, Guwahati, 781014, Assam, India.
Adv Exp Med Biol. 2018;1052:63-74. doi: 10.1007/978-981-10-7572-8_6.
The present study aims at synthesizing gelatin A-pectin complex coacervates and encapsulation of theophylline in the polymer system. Variation and optimization of different reaction parameters such as pH, ratio between the polymers and cross-linker concentration was carried out to attain higher product yield. Relative viscosity, turbidity and UV-visible measurements were done for optimization. The optimum ratio between gelatin A-pectin was fixed at weight ratio 42:8 and pH=3.5. It was further observed that adhesion between the microcapsules decreased by the use of sodium carboxymethyl cellulose (SCMC) to the coacervate. The synthesized microcapsules were characterized by using spectroscopic techniques to assess their formation, drug loading and chemical interaction between theophylline and coacervate. Scanning electron microscopy (SEM) revealed the formation of microcapsules. Study relating to the encapsulation efficiency and swelling of the complex coacervates were also carried out.
本研究旨在合成明胶-果胶复合凝聚物，并将茶碱包埋在聚合物体系中。通过改变和优化不同的反应参数，如 pH 值、聚合物比例和交联剂浓度，以获得更高的产物产率。进行了相对粘度、浊度和紫外-可见测量以进行优化。明胶-果胶的最佳比例固定在重量比 42:8，pH=3.5。进一步观察到，使用羧甲基纤维素钠（CMC）会降低微胶囊之间的附着力。通过光谱技术对合成的微胶囊进行了表征，以评估其形成、载药和茶碱与凝聚物之间的化学相互作用。扫描电子显微镜（SEM）揭示了微胶囊的形成。还进行了关于复合凝聚物的包封效率和溶胀的研究。
