Wahab Awais, Almangush Alhadi, Andersson Leif C, Nieminen Pentti, Salo Tuula
Department of Pathology, University of Helsinki, Helsinki, Finland.
Department of Oral and Maxillofacial Diseases, University of Helsinki, Helsinki, Finland.
Front Oral Health. 2020 Nov 5;1:599421. doi: 10.3389/froh.2020.599421. eCollection 2020.
Astroprincin (APCN, FAM171A1) is a recently characterized transmembrane glycoprotein that is abundant in brain astrocytes and is overexpressed in some tumors. However, the expression and role of APCN is unknown in oral tongue squamous cell carcinoma (OTSCC). Aim of this study was to investigate the expression of APCN in OTSCC tissue samples and to analyze possible association of APCN with clinicopathological features and survival rates. This study included 76 patients treated for OTSCC. Expression of APCN in OTSCC tissue sections was examined by immunohistochemistry with a rabbit polyclonal antibody (MAP346) against APCN. All tumors were scored for intensity and percentage of APCN staining at the superficial, middle, and invasive front areas. High expression of APCN was significantly associated with increased tumor size ( = 0.013) and with OTSCC recurrence ( = 0.026). In this pilot study, we observed that the amount of APCN is associated with the size and recurrence of OTSCC. This finding suggests a role of APCN during OTSCC progression.
星状蛋白（APCN，FAM171A1）是一种最近被鉴定的跨膜糖蛋白，在脑星形胶质细胞中含量丰富，并且在某些肿瘤中过表达。然而，APCN在口腔舌鳞状细胞癌（OTSCC）中的表达及作用尚不清楚。本研究的目的是调查APCN在OTSCC组织样本中的表达，并分析APCN与临床病理特征及生存率之间可能存在的关联。本研究纳入了76例接受OTSCC治疗的患者。使用针对APCN的兔多克隆抗体（MAP346）通过免疫组织化学法检测OTSCC组织切片中APCN的表达。对所有肿瘤在浅表、中间和浸润前沿区域的APCN染色强度和百分比进行评分。APCN的高表达与肿瘤大小增加（P = 0.013）及OTSCC复发（P = 0.026）显著相关。在这项初步研究中，我们观察到APCN的量与OTSCC的大小及复发有关。这一发现提示了APCN在OTSCC进展过程中的作用。
