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分化抑制因子 1 在动脉粥样硬化中的作用及研究进展。

The Role and Research Progress of Inhibitor of Differentiation 1 in Atherosclerosis.

机构信息

Department of Cardiology, Medicine School of Ningbo University, Ningbo, China.

Department of Cardiology, Lihuili Hospital Affiliated to Ningbo University, Ningbo, China.

出版信息

DNA Cell Biol. 2022 Feb;41(2):71-79. doi: 10.1089/dna.2021.0745. Epub 2022 Jan 19.

DOI:10.1089/dna.2021.0745
PMID:35049366
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8863915/
Abstract

Inhibitor of differentiation 1 has a helix-loop-helix (HLH) structure, belongs to a class of molecules known as the HLH trans-acting factor family, and plays an important role in advancing the cell cycle, promoting cell proliferation and inhibiting cell differentiation. Recent studies have confirmed that inhibitor of differentiation 1 plays an important role in the endothelial-mesenchymal transition of vascular endothelial cells, angiogenesis, reendothelialization after injury, and the formation and rupture of atherosclerotic plaques. An in-depth understanding of the role of inhibitor of differentiation 1 in atherosclerosis will provide new ideas and strategies for the treatment of related diseases.

摘要

分化抑制因子 1 具有螺旋-环-螺旋（HLH）结构，属于 HLH 转录因子家族的一类分子，在推动细胞周期、促进细胞增殖和抑制细胞分化方面发挥着重要作用。最近的研究证实，分化抑制因子 1 在血管内皮细胞的内皮-间充质转化、血管生成、损伤后的再内皮化以及动脉粥样硬化斑块的形成和破裂中起着重要作用。深入了解分化抑制因子 1 在动脉粥样硬化中的作用，将为相关疾病的治疗提供新的思路和策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a2dd/8863915/ffc00a792517/dna.2021.0745_figure3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a2dd/8863915/da76050c7a4c/dna.2021.0745_figure1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a2dd/8863915/cf4d564b990d/dna.2021.0745_figure2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a2dd/8863915/ffc00a792517/dna.2021.0745_figure3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a2dd/8863915/da76050c7a4c/dna.2021.0745_figure1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a2dd/8863915/cf4d564b990d/dna.2021.0745_figure2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a2dd/8863915/ffc00a792517/dna.2021.0745_figure3.jpg

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