Mullié A, Lust P, Penninckx J, Vanhove L, Miranda R, Hainaux M, Spincemaille J
Ann Anesthesiol Fr. 1978;19(10):833-41.
Twenty patients suffering from post-ischaemic encephalopathy were treated with high doses of barbiturates during the period immediately following resuscitation. The duration of cerebral ischaemia was assessed retrospectively. The degree of ischaemic damage was evaluated on the one hand by the pupillary signs seen 10 minutes after the reestablishment of the circulation and secondly by enzyme levels in the CSF. This barbiturate load was not associated with major complications and the excretion of barbiturate continued for several days. The clinical signs seen 12 hours after ischaemia and continuous observation of the tracing of the cerebral function monitor made it possible to give an early favourable prognosis from a neurological standpoint. In all the patients (apart from one) in whom there was total cerebral ischaemia for less than 10 minutes, neurological recovery was complete.
20名患有缺血后脑病的患者在复苏后的即刻接受了大剂量巴比妥类药物治疗。脑缺血持续时间通过回顾性评估。缺血损伤程度一方面通过循环恢复10分钟后观察到的瞳孔体征评估，另一方面通过脑脊液中的酶水平评估。这种巴比妥类药物负荷未伴有重大并发症，且巴比妥类药物排泄持续数天。缺血12小时后观察到的临床体征以及对脑功能监测仪记录的持续观察使得从神经学角度能够给出早期良好预后。在所有全脑缺血少于10分钟的患者中（除1例之外），神经功能恢复完全。
