Vaagenes P, Mullie A, Fodstad D T, Abramson N, Safar P
International Resuscitation Research Center, University of Pittsburgh, PA.
Am J Emerg Med. 1994 Nov;12(6):621-4. doi: 10.1016/0735-6757(94)90026-4.
Levels of brain creatine phosphokinase (CPK), glutamic oxalic transaminase, lactate dehydrogenase, and lactate in lumbar cerebrospinal fluid (CSF) were analyzed as an adjunctive study in a randomized clinical trial evaluating the effects of thiopental loading intravenously in comatose survivors of cardiac arrest. Three hospitals participated and a total of 62 cases of enzyme changes were studied. Enzyme levels but not lactate were higher at 48 hours than at 24 hours after restoration of spontaneous circulation. All enzymes were highly correlated with one another at 24 and 48 hours (P < .001). There was a significant negative correlation between cerebral recovery and increased CPK levels at 24 hours (P < .05), and a highly significant correlation with all three enzyme levels at 48 hours (P < .0001). The increase of cytosolic enzyme activity in lumbar CSF reflects permanent brain damage, and there is a relationship between activity levels and cerebral outcome.
在一项评估硫喷妥钠静脉负荷对心脏骤停昏迷幸存者影响的随机临床试验中，对腰椎脑脊液（CSF）中的脑肌酸磷酸激酶（CPK）、谷草转氨酶、乳酸脱氢酶和乳酸水平进行了分析，作为辅助研究。三家医院参与了研究，共研究了62例酶变化情况。自主循环恢复后48小时的酶水平高于24小时，但乳酸水平除外。在24小时和48小时时，所有酶之间均高度相关（P <.001）。24小时时脑恢复与CPK水平升高之间存在显著负相关（P <.05），48小时时与所有三种酶水平均存在高度显著相关性（P <.0001）。腰椎CSF中胞质酶活性的增加反映了永久性脑损伤，且活性水平与脑转归之间存在关联。
