年龄相关性黄斑变性中血管内皮生长因子和基质细胞衍生因子-1α的房水水平
Aqueous Humor Levels of Vascular Endothelial Growth Factor and Stromal Cell-Derived Factor-1α in Age-Related Macular Degeneration.
作者信息
Keles Ali, Erol Yasemin Ozdamar, Ayyildiz Sema Nur, Karaman Suleyman Korhan, Ogus Elmas
机构信息
Department of Ophthalmology, Bilecik Seyh Edebali University Faculty of Medicine, Bilecik, Turkey.
Department of Ophthalmology, University of Health Science, Ulucanlar Eye Training and Research Hospital, Ankara, Turkey.
出版信息
Beyoglu Eye J. 2021 Dec 17;6(4):298-303. doi: 10.14744/bej.2021.49140. eCollection 2021.
OBJECTIVES
This study investigated the contribution of vascular endothelial growth factor (VEGF) and stromal cell-derived factor-1α (SDF-1α) angiogenic mediators in eyes with age-related macular degeneration (AMD).
METHODS
Aqueous humor specimens taken during cataract surgery in 7 cases of intermediate stage (nonexudative) AMD and 7 cases of late stage (exudative) AMD were evaluated using chemiluminescent immunoassay testing in this prospective case-control study. Mediator levels were compared with the normal reference values of 7 patients without any disease other than cataract.
RESULTS
The groups were similar in terms of age and gender (p>0.05). The aqueous humor levels of VEGF in both the intermediate AMD (median: 224.3 pg/mL, range: 44.8-380.4 pg/mL) and late-stage AMD (median: 108.7 pg/mL, range: 61.9-223.5 pg/mL) patients were similar to those of the control group (median: 121.1 pg/mL, range: 24.9-156.6 pg/mL) (p=0.256). Moreover, there was no significant difference in the SDF-1α concentrations between the intermediate AMD (median: 160.9 pg/mL, range 130-166.3 pg/mL), late AMD (median: 161 pg/mL, range: 154.1.9-171.6 pg/mL), and control group values (median: 161 pg/mL, range: 155.2-219 pg/mL) (p=0.763).
CONCLUSION
The aqueous humor levels of VEGF and SDF-1α were within the normal range in patients with intermediate and late-stage AMD.
目的
本研究调查血管内皮生长因子（VEGF）和基质细胞衍生因子-1α（SDF-1α）血管生成介质在年龄相关性黄斑变性（AMD）眼中的作用。
方法
在这项前瞻性病例对照研究中，使用化学发光免疫分析测试对7例中期（非渗出性）AMD和7例晚期（渗出性）AMD患者白内障手术期间采集的房水样本进行评估。将介质水平与7例除白内障外无任何疾病患者的正常参考值进行比较。
结果
两组在年龄和性别方面相似（p>0.05）。中期AMD患者（中位数：224.3 pg/mL，范围：44.8 - 380.4 pg/mL）和晚期AMD患者（中位数：108.7 pg/mL，范围：61.9 - 223.5 pg/mL）房水中VEGF水平与对照组（中位数：121.1 pg/mL，范围：24.9 - 156.6 pg/mL）相似（p = 0.256）。此外，中期AMD（中位数：160.9 pg/mL，范围130 - 166.3 pg/mL）、晚期AMD（中位数：161 pg/mL，范围：154.1 - 171.6 pg/mL）和对照组（中位数：161 pg/mL，范围：155.2 - 219 pg/mL）之间SDF-1α浓度无显著差异（p = 0.763）。
结论
中期和晚期AMD患者房水中VEGF和SDF-1α水平在正常范围内。
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