探讨了（cuniculatum）型的楔形（沟纹）口腔鳞状细胞癌：两例病例的表现及对这一罕见实体的文献回顾。
Cuneiform (cuniculatum) variant of oral squamous cell carcinoma revisited: Presentation of two cases and literature review of a rare entity.
机构信息
The Thyroid, Head and Neck Cancer (THANC) Foundation, New York, New York, USA.
Department of Otolaryngology-Head and Neck Surgery, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
出版信息
Head Neck. 2022 Apr;44(4):E16-E24. doi: 10.1002/hed.26984. Epub 2022 Jan 22.
BACKGROUND
Oral carcinoma cuniculatum (OCC) is a rare, locally aggressive tumor, which tends to invade underlying bone. We present two cases of OCC, one demonstrating invasion of the mandible and the other limited to the tongue.
METHODS
An 87-year-old male presented with a right-sided buccogingival lesion. Biopsy results led to a diagnosis of verrucous hyperplasia, which was later revised to OCC. Additionally, a 94-year-old female presented with a left lateral tongue lesion. A biopsy showed in-situ and invasive keratinizing squamous cell carcinoma that was later defined as a soft tissue OCC.
RESULTS
Following surgical resection, the diagnosis of OCC was established in both patients. We provide a comprehensive literature review of OCC in the context of both case presentations.
CONCLUSIONS
OCC is a rare entity, which has a tendency to be misdiagnosed. We emphasize the importance of recognizing the common features of OCC in order to aid in accurate diagnosis.
背景
口腔蕈状癌（OCC）是一种罕见的、局部侵袭性肿瘤，往往会侵犯下颌骨。我们报告两例 OCC，一例表现为下颌骨侵犯，另一例局限于舌部。
方法
一名 87 岁男性患者出现右侧颊龈病变。活检结果最初诊断为疣状增生，后来修正为 OCC。此外，一名 94 岁女性患者出现左侧舌侧病变。活检显示原位和侵袭性角化鳞状细胞癌，后来被定义为软组织 OCC。
结果
两名患者均通过手术切除后，确诊为 OCC。我们结合病例报告，对 OCC 的文献进行了全面回顾。
结论
OCC 是一种罕见的实体瘤，容易误诊。我们强调认识 OCC 的常见特征的重要性，以便准确诊断。
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