Heinze E, Beischer W, Keller L, Winkler G, Teller W M, Pfeiffer E F
Diabetes. 1978 Jun;27(6):670-6. doi: 10.2337/diab.27.6.670.
C-peptide secretion was studied in eight juvenile diabetics during the remission phase of the disease. The release of C-peptide was measured after a (1) normal intravenous glucose tolerance test, (2) a double glucose tolerance test, (3) an arginine infusion, and (4) after an intravenous glucose tolerance test followed by an arginine infusion. Under all conditions the intravenous glucose load had only a minimal effect on the secretion of C-peptide, while arginine alone or after the intravenous glucose tolerance test stimulated the release of the peptide in all patients. Pretreatment with glucose did not augment the effect of arginine on C-peptide release. The results indicate that during the remission phase of juvenile-onset diabetes the endocrine pancreas does not recognize glucose as and appropriate signal for C-peptide release and cannot transform the amplifying effect of glucose into a higher hormonal secretion rate.
对8名处于疾病缓解期的青少年糖尿病患者的C肽分泌情况进行了研究。在以下情况下测量C肽的释放：(1)正常静脉葡萄糖耐量试验后；(2)双重葡萄糖耐量试验后；(3)精氨酸输注后；(4)静脉葡萄糖耐量试验后再进行精氨酸输注。在所有情况下，静脉注射葡萄糖负荷对C肽分泌的影响极小，而单独使用精氨酸或在静脉葡萄糖耐量试验后，所有患者体内的该肽释放均受到刺激。葡萄糖预处理并未增强精氨酸对C肽释放的作用。结果表明，在青少年发病型糖尿病缓解期，内分泌胰腺不将葡萄糖识别为C肽释放的合适信号，并且无法将葡萄糖的放大作用转化为更高的激素分泌率。
