微阵列分析探讨异构体在胰腺前肿瘤细胞模型中的作用。

Microarray analysis to explore the effect of isoforms in a pancreatic pre-tumor cell model.

机构信息

The First Clinical Medical College, Lanzhou University, Lanzhou 730000, Gansu Province, China.

出版信息

World J Gastroenterol. 2021 Dec 21;27(47):8194-8198. doi: 10.3748/wjg.v27.i47.8194.

DOI:10.3748/wjg.v27.i47.8194

PMID:35068863

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8704271/

Abstract

expression was significantly lower in tumor samples than in corresponding normal samples. expression was significantly positively related to the infiltration levels of T cells, dendritic cells (DCs), immature DCs, cytotoxic cells, Tfh cells, mast cells, B cells, Th1 cells, natural killer (NK) cells, pDCs, neutrophils, and T helper cells (Spearman correlation coefficient > 0.5, < 0.001) and negatively correlated with the infiltration level of NK CD56bright cells. In addition, pancreatic hTERT-HPNE cells treated with three diverse isoforms exhibited changes mainly in the regulation of the epithelial-mesenchymal transition activation pathway.

摘要

在肿瘤样本中的表达明显低于相应的正常样本。表达与 T 细胞、树突状细胞 (DC)、未成熟 DC、细胞毒性细胞、Tfh 细胞、肥大细胞、B 细胞、Th1 细胞、自然杀伤 (NK) 细胞、浆细胞样树突状细胞 (pDC)、中性粒细胞和辅助性 T 细胞的浸润水平呈显著正相关（Spearman 相关系数>0.5，<0.001），与 NK CD56bright 细胞的浸润水平呈负相关。此外，用三种不同的异构体处理的胰腺 hTERT-HPNE 细胞主要表现为上皮-间充质转化激活途径的调控变化。