新加坡肺炎克雷伯菌肝脓肿患者发生脓毒转移性感染的危险因素：一项病例对照研究。
Risk Factors of Septic Metastatic Infection among Patients with Klebsiella pneumoniae Liver Abscess in Singapore: A Case-Control Study.
机构信息
Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore.
Division of Infectious Diseases, Department of Medicine, National University Hospital, National University Health System, Singapore.
出版信息
Am J Trop Med Hyg. 2022 Jan 24;106(3):805-808. doi: 10.4269/ajtmh.21-0623.
Metastatic infection resulting from Klebsiella pneumoniae liver abscess (KPLA) results in high mortality and morbidity. This study aimed to determine the risk factors associated with metastatic infection among patients with KPLA in Singapore. A retrospective case-control analysis among adult patients admitted to the National University Hospital with KPLA between 2013 and 2017 was conducted. Univariate and multivariate regression analysis was conducted. Of the 116 KPLA patients, 38.8% had pulmonary metastatic infection. Length of hospital stay (P = 0.001) and intensive care unit admissions (P = 0.044) were significantly longer and greater, respectively, among the patients with metastatic infection. Sepsis-induced hypotension (adjusted odds ratio [AOR], 4.88; 95% CI, 1.1-21.69), breathlessness (AOR, 5.10; 95% CI, 1.42-18.27), and abscess size (AOR, 1.02; 95% CI, 1.01-1.03) were associated independently with septic metastatic infection. Patients with KPLA who had breathlessness and larger abscess size are at a greater risk of septic metastatic infection.
由肺炎克雷伯菌肝脓肿（KPLA）引起的转移性感染导致高死亡率和发病率。本研究旨在确定新加坡 KPLA 患者发生转移性感染的相关危险因素。对 2013 年至 2017 年间因 KPLA 入住国立大学医院的成年患者进行了回顾性病例对照分析。进行了单变量和多变量回归分析。在 116 例 KPLA 患者中，38.8%发生肺部转移性感染。转移性感染患者的住院时间（P = 0.001）和重症监护病房入住率（P = 0.044）显著延长和增加。感染性休克（调整后的优势比[OR]，4.88；95%置信区间，1.1-21.69）、呼吸困难（OR，5.10；95%置信区间，1.42-18.27）和脓肿大小（OR，1.02；95%置信区间，1.01-1.03）与败血症性转移性感染独立相关。有呼吸困难和更大脓肿大小的 KPLA 患者发生败血症性转移性感染的风险更高。
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