Bridges R S, Feder H H
Horm Behav. 1978 Feb;10(1):30-9. doi: 10.1016/0018-506x(78)90022-3.
The inhibitory effects of progesterone (P), 5 alpha-dihydroprogesterone (5 alpha-DHP), 17 alpha-hydroxyprogesterone (17-HP), and deoxycorticosterone (DOC) upon the rapid onset of maternal behavior induced during late pregnancy in primigravid rats by ovariectomy-hysterectomy (OH) were examined. Progesterone administration at a dosage of 5.0 mg oil vehicle daily (beginning on Day 17 and ending when the subject responded maternally to foster pups) significantly delayed by about 1.5 to 2.0 days the onset of maternal behavior. In contrast, P at dosages of either 1.0 or 2.5 mg daily, 5 alpha-DHP at 5.0 mg administered daily in either an oil or Tween-80 vehicle, 17-HP at 5.0 mg in oil daily, and DOC at dosages of either 5.0 or 10.0 mg in oil daily failed to effect the rapid onset of maternal behavior induced by ovariectomy-hysterectomy on Day 17 of pregnancy. These data suggest that during pregnancy the onset of maternal behavior is inhibited in a rather specific manner by progesterone.
研究了孕酮（P）、5α-双氢孕酮（5α-DHP）、17α-羟孕酮（17-HP）和脱氧皮质酮（DOC）对初孕大鼠在妊娠晚期通过卵巢切除-子宫切除（OH）诱导的母性行为快速出现的抑制作用。以每天5.0mg油剂载体的剂量给予孕酮（从第17天开始，直至受试动物对寄养幼崽表现出母性行为时结束），显著延迟了母性行为的出现约1.5至2.0天。相比之下，每天1.0或2.5mg剂量的P、每天5.0mg以油剂或吐温-80载体给予的5α-DHP、每天5.0mg油剂的17-HP以及每天5.0或10.0mg油剂的DOC，均未能影响在妊娠第17天通过卵巢切除-子宫切除诱导的母性行为的快速出现。这些数据表明，在妊娠期间，孕酮以一种相当特异的方式抑制母性行为的出现。
