Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.
Department of Statistical Sciences, University of Padova, Padova, Italy.
Alzheimers Dement. 2022 Nov;18(11):2167-2175. doi: 10.1002/alz.12554. Epub 2022 Jan 27.
Several investigations have argued for a strong relationship between neuroinflammation and amyloid metabolism but it is still unclear whether inflammation exerts a pro-amyloidogenic effect, amplifies the neurotoxic effect of amyloid, or is protective.
Forty-two patients with acute encephalitis (ENC) and 18 controls underwent an extended cerebrospinal fluid (CSF) panel of inflammatory, amyloid (Aβ40, 42, and 38, sAPP-α, sAPP-β), glial, and neuronal biomarkers. Linear and non-linear correlations between CSF biomarkers were evaluated studying conditional independence relationships.
CSF levels of inflammatory cytokines and neuronal/glial markers were higher in ENC compared to controls, whereas the levels of amyloid-related markers did not differ. Inflammatory markers were not associated with amyloid markers but exhibited a correlation with glial and neuronal markers in conditional independence analysis.
By an extensive CSF biomarkers analysis, this study showed that an acute neuroinflammation state, which is associated with glial activation and neuronal damage, does not influence amyloid homeostasis.
多项研究表明神经炎症与淀粉样代谢之间存在密切关系，但炎症是否具有促淀粉样蛋白形成作用、放大淀粉样蛋白的神经毒性作用，还是具有保护作用，目前仍不清楚。
42 例急性脑炎（ENC）患者和 18 例对照者接受了扩展的脑脊液（CSF）炎症、淀粉样蛋白（Aβ40、42 和 38、sAPP-α、sAPP-β）、神经胶质和神经元生物标志物的检测。通过研究条件独立性关系，评估了 CSF 生物标志物之间的线性和非线性相关性。
与对照组相比，ENC 患者的 CSF 炎症细胞因子和神经胶质/神经元标志物水平更高，而淀粉样蛋白相关标志物水平无差异。在条件独立性分析中，炎症标志物与淀粉样蛋白标志物无关联，但与神经胶质和神经元标志物相关。
通过对广泛的 CSF 生物标志物分析，本研究表明急性神经炎症状态与神经胶质激活和神经元损伤相关，但不影响淀粉样蛋白的动态平衡。
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