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非痴呆老年人脑脊液炎症标志物模式：一项聚类分析

Patterns of CSF Inflammatory Markers in Non-demented Older People: A Cluster Analysis.

作者信息

Peng Yangdi, Chen Bin, Chi Lifen, Zhou Qiang, Shi Zhenjing

机构信息

Department of Respiratory Medicine, Yongjia County Traditional Chinese Medicine Hospital, Wenzhou, China.

Department of Neurology, Ruian People's Hospital, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.

出版信息

Front Aging Neurosci. 2020 Oct 6;12:577685. doi: 10.3389/fnagi.2020.577685. eCollection 2020.

DOI:10.3389/fnagi.2020.577685
PMID:33132899
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7573280/
Abstract

OBJECTIVE

In this study, we aimed to examine if patterns of CSF inflammatory markers are correlated with global cognition, episodic memory, hippocampal volume, and CSF AD-related pathologies among non-demented older people.

METHODS

We included 217 non-demented older individuals, including 87 subjects with normal cognition (NC) and 130 subjects with mild cognitive impairment (MCI) from the Alzheimer's Disease Neuroimaging Initiative (ADNI) study. Hierarchical cluster analysis including nine inflammatory markers in CSF [Tumor necrosis factor-α(TNF-α), TNF-R1, TNF-R2, transforming growth factor-β1 (TGF-β1), TGF-β2, TGF-β3, Interleukin-21 (IL-21), IL-6, and IL-7] was conducted.

RESULTS

We identified two clusters among non-demented older people based on nine inflammatory markers in CSF. Compared to the first cluster, the second cluster showed significantly higher levels of CSF inflammatory markers (TNF-R1, TNF-R2, TGF-β1, TGF-β3, and IL-6). Further, the second cluster was also associated with higher levels of -tau and -tau levels in CSF.

CONCLUSION

We observed a subgroup of non-demented older people characterized by increased levels of inflammatory markers in CSF. Further, this subgroup showed higher levels of -tau and -tau levels in CSF.

摘要

目的

在本研究中，我们旨在探讨脑脊液炎症标志物模式是否与非痴呆老年人的整体认知、情景记忆、海马体积以及脑脊液中与阿尔茨海默病相关的病理变化相关。

方法

我们纳入了217名非痴呆老年人，包括来自阿尔茨海默病神经影像学倡议（ADNI）研究的87名认知正常（NC）受试者和130名轻度认知障碍（MCI）受试者。进行了包括脑脊液中的九种炎症标志物[肿瘤坏死因子-α（TNF-α）、TNF-R1、TNF-R2、转化生长因子-β1（TGF-β1）、TGF-β2、TGF-β3、白细胞介素-21（IL-21）、IL-6和IL-7]的分层聚类分析。

结果

基于脑脊液中的九种炎症标志物，我们在非痴呆老年人中识别出两个聚类。与第一个聚类相比，第二个聚类显示脑脊液炎症标志物（TNF-R1、TNF-R2、TGF-β1、TGF-β3和IL-6）水平显著更高。此外，第二个聚类还与脑脊液中更高水平的-tau和-tau水平相关。

结论

我们观察到一个以脑脊液中炎症标志物水平升高为特征的非痴呆老年亚组。此外，该亚组脑脊液中-tau和-tau水平更高。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b72/7573280/7b795168bb8c/fnagi-12-577685-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b72/7573280/5f782050edce/fnagi-12-577685-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b72/7573280/7b795168bb8c/fnagi-12-577685-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b72/7573280/5f782050edce/fnagi-12-577685-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b72/7573280/7b795168bb8c/fnagi-12-577685-g002.jpg

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