Research Group PLASMANT, Department of Chemistry, University of Antwerp, Universiteitsplein 1, B-2610, Antwerp, Belgium; Centro de Ciências Naturais e Humanas, Universidade Federal do ABC, Avenida dos Estados 5001, CEP 09210-580, Santo André, SP, Brazil.
Research Group PLASMANT, Department of Chemistry, University of Antwerp, Universiteitsplein 1, B-2610, Antwerp, Belgium; Laboratory of Thermal Physics of Multiphase Systems, Arifov Institute of Ion-Plasma and Laser Technologies, Academy of Sciences of Uzbekistan, Durmon yuli str. 33, 100125, Tashkent, Uzbekistan.
Arch Biochem Biophys. 2022 Mar 15;717:109136. doi: 10.1016/j.abb.2022.109136. Epub 2022 Jan 24.
It is well established that lipid aldehydes (LAs) are able to increase the permeability of cell membranes and induce their rupture. However, it is not yet clear how LAs are distributed in phase-separated membranes (PSMs), which are responsible for the transport of selected molecules and intracellular signaling. Thus, we investigate here the distribution of LAs in a PSM by coarse-grained molecular dynamics simulations. Our results reveal that LAs derived from mono-unsaturated lipids tend to accumulate at the interface between the liquid-ordered/liquid-disordered domains, whereas those derived from poly-unsaturated lipids remain in the liquid-disordered domain. These results are important for understanding the effects caused by oxidized lipids in membrane structure, properties and organization.
已有研究证实，脂质醛（LAs）能够增加细胞膜的通透性并诱导其破裂。然而，目前尚不清楚 LAs 在相分离膜（PSMs）中的分布情况，PSMs 负责选择性分子的运输和细胞内信号转导。因此，我们在此通过粗粒化分子动力学模拟研究了 LAs 在 PSM 中的分布。我们的结果表明，源自单不饱和脂质的 LAs 倾向于在有序相/无序相之间的界面处聚集，而源自多不饱和脂质的 LAs 则留在无序相区。这些结果对于理解氧化脂质在膜结构、性质和组织中引起的影响具有重要意义。
