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Sepsis endotypes: The early bird still gets the worm.
EBioMedicine. 2022 Feb;76:103832. doi: 10.1016/j.ebiom.2022.103832. Epub 2022 Jan 24.
2
Classification of patients with sepsis according to blood genomic endotype: a prospective cohort study.
Lancet Respir Med. 2017 Oct;5(10):816-826. doi: 10.1016/S2213-2600(17)30294-1. Epub 2017 Aug 29.
3
Evidence of Endotypes in Pediatric Acute Hypoxemic Respiratory Failure Caused by Sepsis.
Pediatr Crit Care Med. 2019 Feb;20(2):110-112. doi: 10.1097/PCC.0000000000001808.
5
Validation of Inflammopathic, Adaptive, and Coagulopathic Sepsis Endotypes in Coronavirus Disease 2019.
Crit Care Med. 2021 Feb 1;49(2):e170-e178. doi: 10.1097/CCM.0000000000004786.
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The road to precision medicine in sepsis: blood transcriptome endotypes.
Lancet Respir Med. 2017 Oct;5(10):767-768. doi: 10.1016/S2213-2600(17)30297-7. Epub 2017 Aug 29.
9
The early bird catches the worm.
Crit Care Med. 2005 Oct;33(10):2412-4. doi: 10.1097/01.ccm.0000182998.90016.ef.
10
The Early Bird Gets the Worm.
Ann Thorac Surg. 2021 Nov;112(5):1671. doi: 10.1016/j.athoracsur.2020.11.036. Epub 2020 Dec 23.

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Is "pre-sepsis" the new sepsis? A narrative review.
PLoS Pathog. 2025 Jul 31;21(7):e1013372. doi: 10.1371/journal.ppat.1013372. eCollection 2025 Jul.
2
Therapeutic impact of human trophoblast stem cells in peritoneal and pneumonia-induced sepsis in mice.
Stem Cell Res Ther. 2025 Jul 21;16(1):394. doi: 10.1186/s13287-025-04479-z.
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Mathematical model of the inflammatory response to acute and prolonged lipopolysaccharide exposure in humans.
NPJ Syst Biol Appl. 2024 Dec 5;10(1):146. doi: 10.1038/s41540-024-00473-y.
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Utility of monocyte HLA-DR and rationale for therapeutic GM-CSF in sepsis immunoparalysis.
Front Immunol. 2023 Feb 7;14:1130214. doi: 10.3389/fimmu.2023.1130214. eCollection 2023.

本文引用的文献

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Predicting sepsis severity at first clinical presentation: The role of endotypes and mechanistic signatures.
EBioMedicine. 2022 Jan;75:103776. doi: 10.1016/j.ebiom.2021.103776. Epub 2022 Jan 10.
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Post-sepsis immunosuppression depends on NKT cell regulation of mTOR/IFN-γ in NK cells.
J Clin Invest. 2020 Jun 1;130(6):3238-3252. doi: 10.1172/JCI128075.
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Prognostic and predictive enrichment in sepsis.
Nat Rev Nephrol. 2020 Jan;16(1):20-31. doi: 10.1038/s41581-019-0199-3. Epub 2019 Sep 11.
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Heterogeneity in sepsis: new biological evidence with clinical applications.
Crit Care. 2019 Mar 9;23(1):80. doi: 10.1186/s13054-019-2372-2.
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Transcriptomic Signatures in Sepsis and a Differential Response to Steroids. From the VANISH Randomized Trial.
Am J Respir Crit Care Med. 2019 Apr 15;199(8):980-986. doi: 10.1164/rccm.201807-1419OC.
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Sepsis and septic shock.
Nat Rev Dis Primers. 2016 Jun 30;2:16045. doi: 10.1038/nrdp.2016.45.
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Shared and Distinct Aspects of the Sepsis Transcriptomic Response to Fecal Peritonitis and Pneumonia.
Am J Respir Crit Care Med. 2017 Aug 1;196(3):328-339. doi: 10.1164/rccm.201608-1685OC.
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Why have clinical trials in sepsis failed?
Trends Mol Med. 2014 Apr;20(4):195-203. doi: 10.1016/j.molmed.2014.01.007. Epub 2014 Feb 24.

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