神经原性膀胱和尿路血吸虫病患者的膀胱癌：它们是同一种肿瘤吗？
Bladder carcinomas in patients with neurogenic bladder and urinary schistosomiasis: are they the same tumors?
机构信息
Department of Medical and Surgical Sciences and Translational Medicine, Sapienza Univeristà di Roma, Sant 'Andrea University Hospital, Via di Grottarossa 1035, 00189, Rome, Italy.
Sorbonne University, GRC n°5, ONCOTYPE-URO, Tenon Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France.
出版信息
World J Urol. 2022 Aug;40(8):1949-1959. doi: 10.1007/s00345-022-03941-4. Epub 2022 Jan 29.
PURPOSE
The aim of our study was to evaluate and compare the expression of different immunohistochemical markers in Bladder Carcinomas (BC) in patients with Neurogenic Bladder (NB) and Urinary Schistosomiasis (US) infection.
MATERIALS AND METHODS
We collected tissue samples from patients with Neurogenic Bladder and Bladder Carcinoma (NBC Group) and from patients with Urinary Schistosomiasis infection and Bladder Carcinoma (SBC Group). We compared to these two groups to control samples from resection from patients with Urinary Schistosomiasis without Bladder Carcinoma (US Group); we also investigate patients' characteristics according to urothelial transitional cell carcinoma (TCC), and squamous cell carcinoma (SCC) histopathological differentiation. The expression of markers in all groups (CK7, CK14, CK20, FoxP3, GATA3, STAG2, CD3, CD8, Ki67, and P53) was analyzed using immunohistochemistry of tissue micro-array sections (TMA).
RESULTS
Overall, 136 patients were included in the study (n = 72 in the NBC group, n = 33 in the SBC group, and n = 31 in the US group). In the TCC subgroup, the expression of CK7, CK14, CK20, and Ki67 was significantly higher compared to US controls (p 0.002; p < 0.001; p 0.036; p < 0.001). In the SCC subgroup, the expression of CK7, CK14, and CK20 was significantly higher compared to US controls (p 0.007; p < 0.001; p 0.005). Both in TCC and SCC subgroups, no difference in the expression of any tested markers was found comparing NBC and SBC groups. In US group, a significant higher expression of STAG2 was found compared to SCC subgroup (p 0.005).
CONCLUSION
Based on our results, the profile of immunohistochemical biomarkers' expression in both NBC and SBC groups is similar.
目的
我们的研究旨在评估和比较神经源性膀胱（NB）和尿路血吸虫病（US）感染患者膀胱癌（BC）中不同免疫组织化学标志物的表达。
材料与方法
我们收集了神经源性膀胱癌和膀胱癌（NBC 组）患者以及尿路血吸虫病合并膀胱癌（SBC 组）患者的组织样本。我们将这些两组与没有膀胱癌的尿路血吸虫病患者的切除标本（US 组）进行比较；我们还根据尿路上皮移行细胞癌（TCC）和鳞状细胞癌（SCC）的组织病理学分化对患者特征进行了调查。使用组织微阵列切片（TMA）的免疫组织化学分析了所有组（CK7、CK14、CK20、FoxP3、GATA3、STAG2、CD3、CD8、Ki67 和 P53）的标志物表达。
结果
总体而言，共有 136 名患者纳入研究（NBC 组 72 例，SBC 组 33 例，US 组 31 例）。在 TCC 亚组中，与 US 对照组相比，CK7、CK14、CK20 和 Ki67 的表达明显更高（p<0.002;p<0.001;p<0.036;p<0.001）。在 SCC 亚组中，与 US 对照组相比，CK7、CK14 和 CK20 的表达明显更高（p<0.007;p<0.001;p<0.005）。在 TCC 和 SCC 亚组中，比较 NBC 和 SBC 组，未发现任何测试标志物表达的差异。在 US 组中，与 SCC 亚组相比，STAG2 的表达明显更高（p<0.005）。
结论
根据我们的结果，NBC 和 SBC 两组的免疫组织化学生物标志物表达谱相似。
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