Rousseau Abigail C, Riggan Kirsten A, Schenone Mauro H, Whitford Kevin J, Pittock Siobhan T, Allyse Megan A
Biomedical Ethics Research Program, Mayo Clinic Rochester, Rochester, MN, USA.
Department of Obstetrics & Gynecology, Division of Maternal and Fetal Medicine, Mayo Clinic, Rochester, MN, USA.
J Perinat Med. 2022 Jan 31;50(5):519-527. doi: 10.1515/jpm-2021-0476. Print 2022 Jun 27.
The practice of maternal-fetal surgery (MFS) has expanded from lethal fetal conditions to conditions which are significantly disabling but not a lethal fetal abnormality. The inclusion of myelomeningocele within the scope of MFS in the 1990s sparked a renewed debate over the ethics of MFS. While demonstrating increasing efficacy and range of application, MFS continues to be ethically fraught due to the inherent tension between maternal and fetal interests. Ethical issues central to MFS include the patienthood of the fetus; the balance of risks and benefits between the woman and fetus; informed consent for experimental procedures; and determination of conditions that meet ethical qualifications for MFS intervention. These concerns are likely to persist and evolve as perinatal medicine continues to advance. Here we summarize the current state of MFS ethics, highlighting the major positions in the literature thus far as well as examine future directions. It is essential robust discussions of these important issues continue both to ensure ethical medical practice and to provide support to clinicians, pregnant women, and their families.
母胎手术(MFS)的实践范围已从致死性胎儿疾病扩展到严重致残但并非致死性胎儿异常的疾病。20世纪90年代将脊髓脊膜膨出纳入MFS的范围引发了关于MFS伦理的新一轮辩论。虽然MFS的疗效和应用范围不断扩大,但由于母体和胎儿利益之间固有的矛盾,MFS在伦理上仍然充满争议。MFS核心的伦理问题包括胎儿的患者身份;女性和胎儿之间风险与益处的平衡;实验性手术的知情同意;以及确定符合MFS干预伦理标准的疾病状况。随着围产期医学的不断发展,这些问题可能会持续存在并演变。在此,我们总结MFS伦理的现状,突出迄今为止文献中的主要观点,并探讨未来方向。对这些重要问题进行充分的讨论至关重要,这既能确保符合伦理的医疗实践,又能为临床医生、孕妇及其家庭提供支持。