Department of Pathology, Binzhou Medical University Hospital, Binzhou, 256603, Shandong Province, China.
BMC Urol. 2022 Jan 29;22(1):9. doi: 10.1186/s12894-022-00963-3.
Leiomyoma of the seminal vesicle is a rare leiomyoma characterized by the formation of benign leiomyomatous tissue within the seminal vesicle. Although histologically benign, excessive size can lead to urinary system disease if left untreated. Herein, we report a case of a seminal vesicle epithelioid leiomyoma.
A 36-year-old Chinese man sought medical attention at our hospital for urination pain and hemospermia. CT showed a 5.3 cm × 5.0 cm seminal vesicle mass with a mixed density in the right seminal vesicle. The gross specimen showed light yellow, gray, and white tissues, with softness and hemorrhage in some places. Histologically, it showed classic spindle cell proliferation, with spindle cells arranged in fascicles, and mitosis was rare. Immunohistochemistry showed frequent expression of smooth muscle markers, such as calponin, SMA, and desmin. A diagnosis of epithelioid leiomyoma was proposed according to the immunohistochemical findings and morphology. The patient did not receive adjuvant therapy. There was no evidence of tumor recurrence in the 10 months after surgery.
We report the first case of epithelioid leiomyoma in the seminal vesicle. This disease should be included in the differential diagnostic list of seminal vesicle tumors with epithelioid morphology.
精囊平滑肌瘤是一种罕见的平滑肌瘤，其特征是在精囊内形成良性平滑肌瘤组织。虽然组织学上是良性的，但如果不治疗，过大的肿瘤可能会导致泌尿系统疾病。在此，我们报告一例精囊上皮样平滑肌瘤。
一名 36 岁的中国男性因排尿疼痛和血精到我院就诊。CT 显示右侧精囊有一个 5.3cm×5.0cm 的精囊肿块，密度混杂。大体标本显示浅黄色、灰色和白色组织，部分质地柔软，有出血。组织学上表现为典型的梭形细胞增生，梭形细胞呈束状排列，有丝分裂少见。免疫组化显示平滑肌标志物如钙调蛋白、SMA 和结蛋白频繁表达。根据免疫组化结果和形态学，提出上皮样平滑肌瘤的诊断。患者未接受辅助治疗。术后 10 个月未见肿瘤复发迹象。
我们报告首例精囊上皮样平滑肌瘤。这种疾病应纳入具有上皮样形态的精囊肿瘤的鉴别诊断列表中。
