鼠带绦虫在大鼠体内长期存活机制的研究。
Studies on the mechanism of long term survival of Taenia taeniaeformis in rats.
作者信息
Kwa B H, Liew F Y
出版信息
J Helminthol. 1978 Mar;52(1):1-6. doi: 10.1017/s0022149x00005046.
An attempt was made to determine if blocking antibody is involved in protecting cysticerci of Taenia taeniaeformis against a host immune response. Immunoflourescence microscopy confirmed that host antibody is presnet on the parasite surface within the capsule. To test if the larvae can still survive after such a coat of blocking antibody is removed, the larvae were trysinised and then implanted into recipients. The results indicate that blocking antibody could be involved in the survival of 1 year old established larvae. Untrypsinised larvae were normal 14 days after implantation into control or immunised rats. Trypsinised larvae implanted in control rats were alive but showed on intense cell adherence on their surface. On the other hand, trypsinised larvae implanted into immunised rats were dead and completely encapsulated. However, experiments with 1 month old larvae were inconclusive.
研究人员试图确定封闭抗体是否参与保护豆状带绦虫囊尾蚴免受宿主免疫反应的影响。免疫荧光显微镜检查证实，宿主抗体存在于囊内寄生虫表面。为了测试去除这种封闭抗体涂层后幼虫是否仍能存活，将幼虫用胰蛋白酶处理后植入受体。结果表明，封闭抗体可能与1岁成熟幼虫的存活有关。未用胰蛋白酶处理的幼虫在植入对照或免疫大鼠14天后正常。植入对照大鼠的经胰蛋白酶处理的幼虫存活，但表面有强烈的细胞黏附。另一方面，植入免疫大鼠的经胰蛋白酶处理的幼虫死亡并被完全包囊。然而，1月龄幼虫的实验结果尚无定论。
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