Department of Epidemiology and Statistics, School of Public Health, Guilin Medical University, Guilin, China.
Asia Pac J Clin Oncol. 2022 Dec;18(6):506-514. doi: 10.1111/ajco.13748. Epub 2022 Jan 30.
As an important transcription factor that is widely expressed in most tissues of the human body, Myc-associated zinc finger protein (MAZ) has been reported highly expressed in many malignant tumors and thought to be a promising therapeutic target for cancer treatment. In this review, we aim to offer a comprehensive understanding of MAZ regulation in malignant tumors. The carboxy terminal of MAZ protein contains six C2H2 zinc fingers, and its regulation of transcription is based on the interaction between the GC-rich DNA binding sites of target genes and its carboxy-terminal zinc finger motifs. MAZ protein has been found to activate or inhibit the transcriptional initiation process of many target genes, as well as play an important role in the transcriptional termination process of some target genes, so MAZ poses dual regulatory functions in the initiation and termination process of gene transcription. Through the transcriptional regulation of c-myc and Ras gene family, MAZ poses an important role in the occurrence and development of breast cancer, pancreatic cancer, prostate cancer, glioblastoma, neuroblastoma, and other malignant tumors. Our review shows a vital role of MAZ in many malignant tumors and provides novel insight for cancer diagnosis and treatment.
作为一种广泛表达于人体大多数组织的重要转录因子，Myc 相关锌指蛋白（MAZ）在许多恶性肿瘤中呈高表达，被认为是癌症治疗有前途的治疗靶点。在这篇综述中，我们旨在全面了解 MAZ 在恶性肿瘤中的调控作用。MAZ 蛋白的羧基末端含有六个 C2H2 锌指，其转录调控是基于靶基因的富含 GC 的 DNA 结合位点与其羧基末端锌指基序之间的相互作用。已经发现 MAZ 蛋白可以激活或抑制许多靶基因的转录起始过程，以及在一些靶基因的转录终止过程中发挥重要作用，因此 MAZ 在基因转录的起始和终止过程中具有双重调节功能。通过对 c-myc 和 Ras 基因家族的转录调控，MAZ 在乳腺癌、胰腺癌、前列腺癌、胶质母细胞瘤、神经母细胞瘤等恶性肿瘤的发生发展中起着重要作用。我们的综述表明 MAZ 在许多恶性肿瘤中具有重要作用，并为癌症的诊断和治疗提供了新的思路。
