• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Complete and Prolonged Response to Immune Checkpoint Blockade in -Mutated Colorectal Cancer.

作者信息

Silberman Robyn, F Steiner David, Lo Amy A, Gomez Adam, Zehnder James L, Chu Gilbert, Suarez Carlos J

机构信息

Stanford University, Stanford, CA.

University of Arizona, Phoenix, AZ.

出版信息

JCO Precis Oncol. 2019 Dec;3:1-5. doi: 10.1200/PO.18.00214.

DOI:10.1200/PO.18.00214
PMID:35100706
Abstract
摘要

相似文献

1
Complete and Prolonged Response to Immune Checkpoint Blockade in -Mutated Colorectal Cancer.KRAS 突变型结直肠癌对免疫检查点阻断的完全且持久反应
JCO Precis Oncol. 2019 Dec;3:1-5. doi: 10.1200/PO.18.00214.
2
Colorectal cancer: A paradigmatic model for cancer immunology and immunotherapy.结直肠癌：癌症免疫学和免疫治疗的典范模型。
Mol Aspects Med. 2019 Oct;69:123-129. doi: 10.1016/j.mam.2019.05.003. Epub 2019 Jun 4.
3
Morphological, immunophenotypical and molecular features of hypermutation in colorectal carcinomas with mutations in DNA polymerase ε (POLE).DNA 聚合酶 ε（POLE）基因突变的结直肠癌中超突变的形态学、免疫表型和分子特征。
Histopathology. 2020 Feb;76(3):366-374. doi: 10.1111/his.13984. Epub 2019 Dec 1.
4
Tumor-Secreted Extracellular Vesicles Regulate T-Cell Costimulation and Can Be Manipulated To Induce Tumor-Specific T-Cell Responses.肿瘤分泌的细胞外囊泡调节 T 细胞共刺激，并可被操纵以诱导肿瘤特异性 T 细胞反应。
Gastroenterology. 2021 Aug;161(2):560-574.e11. doi: 10.1053/j.gastro.2021.04.036. Epub 2021 Apr 23.
5
FAP positive fibroblasts induce immune checkpoint blockade resistance in colorectal cancer via promoting immunosuppression.FAP阳性成纤维细胞通过促进免疫抑制诱导结直肠癌对免疫检查点阻断产生抗性。
Biochem Biophys Res Commun. 2017 May 20;487(1):8-14. doi: 10.1016/j.bbrc.2017.03.039. Epub 2017 Mar 14.
6
Immune Checkpoint Blockade in Lower Gastrointestinal Cancers: A Systematic Review.免疫检查点阻断在胃肠道肿瘤中的应用：一项系统性综述。
Ann Surg Oncol. 2021 Nov;28(12):7463-7473. doi: 10.1245/s10434-021-10192-x. Epub 2021 May 28.
7
The Emergence of Immune-checkpoint Inhibitors in Colorectal Cancer Therapy.免疫检查点抑制剂在结直肠癌治疗中的出现。
Curr Drug Targets. 2021;22(9):1021-1033. doi: 10.2174/1389450122666210204204415.
8
Relationships Between Immune Landscapes, Genetic Subtypes and Responses to Immunotherapy in Colorectal Cancer.结直肠癌免疫图谱、遗传亚型与免疫治疗应答的关系。
Front Immunol. 2020 Mar 6;11:369. doi: 10.3389/fimmu.2020.00369. eCollection 2020.
9
Mutations in DNA damage response pathways as a potential biomarker for immune checkpoint blockade efficacy: evidence from a seven-cancer immunotherapy cohort.DNA 损伤反应通路突变作为免疫检查点阻断疗效的潜在生物标志物：来自七个癌症免疫治疗队列的证据。
Aging (Albany NY). 2021 Nov 8;13(21):24136-24154. doi: 10.18632/aging.203670.
10
The somatic POLE P286R mutation defines a unique subclass of colorectal cancer featuring hypermutation, representing a potential genomic biomarker for immunotherapy.体细胞POLE P286R突变定义了一类具有高突变特征的独特结直肠癌亚类，代表了一种潜在的免疫治疗基因组生物标志物。
Oncotarget. 2016 Oct 18;7(42):68638-68649. doi: 10.18632/oncotarget.11862.

引用本文的文献

1
Patient-derived colorectal microtumors predict response to anti-PD-1 therapy.患者来源的结直肠微小肿瘤可预测对抗PD-1治疗的反应。
Front Immunol. 2025 Aug 12;16:1640500. doi: 10.3389/fimmu.2025.1640500. eCollection 2025.
2
Tumoral programmed cell death 1 (PD1) expression in endometrial carcinoma is a prognostic marker for patient outcome.肿瘤程序性细胞死亡蛋白 1（PD1）在子宫内膜癌中的表达是患者预后的一个预测指标。
Int J Gynecol Cancer. 2024 Nov 4;34(11):1711-1718. doi: 10.1136/ijgc-2023-005188.
3
Deep learning for dual detection of microsatellite instability and POLE mutations in colorectal cancer histopathology.
深度学习用于结直肠癌组织病理学中微卫星不稳定性和POLE突变的双重检测
NPJ Precis Oncol. 2024 May 23;8(1):115. doi: 10.1038/s41698-024-00592-z.
4
Circulating Tumor DNA Response and Minimal Residual Disease Assessment in DNA Polymerase Epsilon-Mutated Colorectal Cancer Undergoing Immunotherapy.接受免疫治疗的DNA聚合酶ε突变型结直肠癌中循环肿瘤DNA反应与微小残留病评估
Cureus. 2023 Aug 12;15(8):e43391. doi: 10.7759/cureus.43391. eCollection 2023 Aug.
5
POLE-Mutant Colon Cancer Treated with PD-1 Blockade Showing Clearance of Circulating Tumor DNA and Prolonged Disease-Free Interval.POLE 突变型结直肠癌经 PD-1 阻断治疗后，循环肿瘤 DNA 清除和无疾病间期延长。
Genes (Basel). 2023 May 8;14(5):1054. doi: 10.3390/genes14051054.
6
Case report: POLE (P286R) mutation in a case of recurrent intestinal leakage and its treatment.病例报告：一例复发性肠漏病例中的POLE（P286R）突变及其治疗
Front Oncol. 2023 Mar 16;13:1028179. doi: 10.3389/fonc.2023.1028179. eCollection 2023.
7
Functional landscapes of POLE and POLD1 mutations in checkpoint blockade-dependent antitumor immunity.POLE 和 POLD1 突变在依赖于检查点阻断的抗肿瘤免疫中的功能景观。
Nat Genet. 2022 Jul;54(7):996-1012. doi: 10.1038/s41588-022-01108-w. Epub 2022 Jul 11.
8
Pathological complete response to immune checkpoint inhibitor in patients with colorectal cancer liver metastases harboring exonuclease domain mutation.结直肠癌肝转移患者携带外切酶结构域突变对免疫检查点抑制剂的病理完全缓解。
J Immunother Cancer. 2022 Jul;10(7). doi: 10.1136/jitc-2022-004487.
9
High prevalence of unusual KRAS, NRAS, and BRAF mutations in POLE-hypermutated colorectal cancers.POLE 超突变型结直肠癌中常见的 KRAS、NRAS 和 BRAF 突变。
Mol Oncol. 2022 Sep;16(17):3055-3065. doi: 10.1002/1878-0261.13257. Epub 2022 Jul 14.
10
Atypical Mutations in Metastatic Colorectal Cancer.转移性结直肠癌中的非典型突变
JCO Precis Oncol. 2019 Dec;3:1-11. doi: 10.1200/PO.19.00136.