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Potentially Curative Targeted Therapy for Undifferentiated High-Grade Sarcoma Developing After Malignant Transformation of a V600E-Mutated Ameloblastic Fibroma.

作者信息

Zhukov Nikolay, Mareeva Yulia, Konovalov Dmitry, Druy Alexander, Grachev Nikolay, Litvinov Dmitry

机构信息

Dmitry Rogachev National Research Center of Hematology, Oncology, and Immunology, Moscow, Russia.

Pirogov Russian National Research Medical University, Moscow, Russia.

出版信息

JCO Precis Oncol. 2019 Dec;3:1-6. doi: 10.1200/PO.19.00282.

DOI:10.1200/PO.19.00282
PMID:35100728
Abstract
摘要

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MicroRNA-126 suppresses proliferation of undifferentiated (BRAF(V600E) and BRAF(WT)) thyroid carcinoma through targeting PIK3R2 gene and repressing PI3K-AKT proliferation-survival signalling pathway.微小RNA-126通过靶向PIK3R2基因并抑制PI3K-AKT增殖-存活信号通路来抑制未分化型（BRAF(V600E)和BRAF(WT)）甲状腺癌的增殖。
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Multiple proliferation-survival signalling pathways are simultaneously active in BRAF V600E mutated thyroid carcinomas.多种增殖-存活信号通路在BRAF V600E突变型甲状腺癌中同时处于激活状态。
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引用本文的文献

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Head Neck Pathol. 2025 Aug 8;19(1):99. doi: 10.1007/s12105-025-01817-8.
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Rapid but nondurable response of a exon 15 double-mutated spindle cell sarcoma to a combination of BRAF and MEK inhibitors.外显子15双突变梭形细胞肉瘤对BRAF和MEK抑制剂联合治疗的快速但不持久的反应。
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Anti-MAPK Targeted Therapy for Ameloblastoma: Case Report with a Systematic Review.
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Malignant Odontogenic Tumours: A Systematic Review of Cases Reported in Literature.恶性牙源性肿瘤：文献报道病例的系统评价
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Head Neck Pathol. 2021 Dec;15(4):1265-1283. doi: 10.1007/s12105-021-01347-z. Epub 2021 Jun 14.