Section of Cardiac Pacing and Electrophysiology, Department of Cardiovascular Medicine, Cleveland, OH.
Section of Heart Failure, Department of Cardiovascular Medicine, Cleveland, OH.
Chest. 2022 May;161(5):1360-1369. doi: 10.1016/j.chest.2022.01.033. Epub 2022 Jan 31.
Direct oral anticoagulants (DOACs) are increasingly used in clinical practice and have become essential in the management of atrial fibrillation and VTE. The enthusiasm for DOACs has fueled the off-label application of these agents in cardiopulmonary disease, and their use has often outpaced the evidence supporting their application. This article reviews the evidence and current off-label use of DOACs in various cardiopulmonary disease states.
直接口服抗凝剂（DOACs）在临床实践中的应用日益增多，在房颤和 VTE 的管理中已成为不可或缺的药物。DOACs 的应用热潮推动了这些药物在心肺疾病中的超适应证应用，其应用速度往往超过了支持其应用的证据。本文综述了 DOACs 在各种心肺疾病状态下的证据和目前的超适应证应用。
