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了解性激素在跨性别群体癌症中的作用。

Understanding the role of sex hormones in cancer for the transgender community.

机构信息

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.

Brighton & Sussex University Hospitals NHS Trust, Brighton, UK; Welsh Gender Service, Cardiff and Vale University Health Board, Cardiff, UK.

出版信息

Trends Cancer. 2022 Apr;8(4):273-275. doi: 10.1016/j.trecan.2022.01.005. Epub 2022 Jan 31.

DOI:10.1016/j.trecan.2022.01.005
PMID:35101413
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8930500/
Abstract

Sex hormones are crucial for the body's development and function. Therefore, many transgender people seek hormone therapy as part of their transition. However, sex hormones modulate cancer risk. Studying sex hormones in cisgender and transgender populations will improve our knowledge of their biological role in cancer and reduce health disparities.

摘要

性激素对于身体的发育和功能至关重要。因此，许多跨性别者寻求激素疗法作为其转变过程的一部分。然而，性激素会调节癌症风险。研究顺性别和跨性别人群中的性激素将提高我们对其在癌症中的生物学作用的认识，并减少健康差距。

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BJU Int. 2022 Apr;129(4):491-497. doi: 10.1111/bju.15575. Epub 2021 Aug 30.
2
Endogenous hormones and risk of invasive breast cancer in pre- and post-menopausal women: findings from the UK Biobank.内源性激素与绝经前和绝经后妇女浸润性乳腺癌风险：来自英国生物银行的研究结果。
Br J Cancer. 2021 Jul;125(1):126-134. doi: 10.1038/s41416-021-01392-z. Epub 2021 Apr 16.
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Cancer Stage, Treatment, and Survival Among Transgender Patients in the United States.
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J Immunol Res. 2024 Oct 24;2024:8481761. doi: 10.1155/2024/8481761. eCollection 2024.
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Epigenetic developmental mechanisms underlying sex differences in cancer.癌症中性别差异的表观遗传发育机制。
J Clin Invest. 2024 Jul 1;134(13):e180071. doi: 10.1172/JCI180071.
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medRxiv. 2024 Mar 26:2024.03.24.24304777. doi: 10.1101/2024.03.24.24304777.
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