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Efficacy of CDK9 inhibition in therapy of post-myeloproliferative neoplasm (MPN) secondary (s) AML cells.

作者信息

Fiskus Warren, Manshouri Taghi, Birdwell Christine, Mill Christopher P, Masarova Lucia, Bose Prithviraj, Kadia Tapan M, Daver Naval, DiNardo Courtney D, Borthakur Gautam, Khoury Joseph D, Verstovsek Srdan, Bhalla Kapil N

机构信息

The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA.

出版信息

Blood Cancer J. 2022 Jan 31;12(1):23. doi: 10.1038/s41408-022-00618-4.

DOI:10.1038/s41408-022-00618-4
PMID:35102145
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8803998/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a25/8803998/510b9143c8bc/41408_2022_618_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a25/8803998/606dd0983b64/41408_2022_618_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a25/8803998/510b9143c8bc/41408_2022_618_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a25/8803998/606dd0983b64/41408_2022_618_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a25/8803998/510b9143c8bc/41408_2022_618_Fig2_HTML.jpg

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本文引用的文献

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Targeting CDK9 for Anti-Cancer Therapeutics.靶向CDK9用于抗癌治疗。
Cancers (Basel). 2021 May 1;13(9):2181. doi: 10.3390/cancers13092181.
2
CDK9: A Comprehensive Review of Its Biology, and Its Role as a Potential Target for Anti-Cancer Agents.细胞周期蛋白依赖性激酶9:对其生物学特性及其作为抗癌药物潜在靶点作用的全面综述
Front Oncol. 2021 May 10;11:678559. doi: 10.3389/fonc.2021.678559. eCollection 2021.
3
Superior efficacy of co-targeting GFI1/KDM1A and BRD4 against AML and post-MPN secondary AML cells.联合靶向 GFI1/KDM1A 和 BRD4 对 AML 和 MPN 后发性 AML 细胞的更优疗效。
骨髓增殖性肿瘤转化为急性髓系白血病的防治
Haematologica. 2025 Apr 1;110(4):828-839. doi: 10.3324/haematol.2023.283950. Epub 2024 Oct 24.
4
Treatment approach and outcomes of patients with accelerated/blast-phase myeloproliferative neoplasms in the current era.当代加速/急变期骨髓增殖性肿瘤患者的治疗方法和结局。
Blood Adv. 2024 Jul 9;8(13):3468-3477. doi: 10.1182/bloodadvances.2024012880.
5
Recent Advances towards the Understanding of Secondary Acute Myeloid Leukemia Progression.对继发性急性髓系白血病进展认识的最新进展
Life (Basel). 2024 Feb 27;14(3):309. doi: 10.3390/life14030309.
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Mechanisms of myeloid leukemogenesis: Current perspectives and therapeutic objectives.髓系白血病发生机制:当前观点与治疗目标。
Blood Rev. 2023 Jan;57:100996. doi: 10.1016/j.blre.2022.100996. Epub 2022 Aug 2.
Blood Cancer J. 2021 May 20;11(5):98. doi: 10.1038/s41408-021-00487-3.
4
Leukemia secondary to myeloproliferative neoplasms.继发于骨髓增生性肿瘤的白血病。
Blood. 2020 Jul 2;136(1):61-70. doi: 10.1182/blood.2019000943.
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Promoter-proximal pausing of RNA polymerase II: a nexus of gene regulation.RNA 聚合酶 II 的启动子近端暂停:基因调控的枢纽。
Genes Dev. 2019 Aug 1;33(15-16):960-982. doi: 10.1101/gad.325142.119. Epub 2019 May 23.
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Pharmacological perturbation of CDK9 using selective CDK9 inhibition or degradation.使用选择性 CDK9 抑制或降解来对 CDK9 进行药理学干扰。
Nat Chem Biol. 2018 Feb;14(2):163-170. doi: 10.1038/nchembio.2538. Epub 2017 Dec 18.
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Targeting cistrome and dysregulated transcriptome of post-MPN sAML.靶向骨髓增殖性肿瘤后急性髓系白血病的顺式作用元件组和失调转录组
Oncotarget. 2017 Oct 11;8(55):93301-93302. doi: 10.18632/oncotarget.21752. eCollection 2017 Nov 7.
10
Identification of Atuveciclib (BAY 1143572), the First Highly Selective, Clinical PTEFb/CDK9 Inhibitor for the Treatment of Cancer.首个用于治疗癌症的高选择性临床PTEFb/CDK9抑制剂阿图维西利布(BAY 1143572)的鉴定。
ChemMedChem. 2017 Nov 8;12(21):1776-1793. doi: 10.1002/cmdc.201700447. Epub 2017 Oct 16.